To compare respiratory muscle strength recovery using ultrasound after neuromuscular reversal with Neostigmine versus Sugammadex.

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2024/01/061766
• Lead Sponsor: Maulana Azad Medical College and associated Lok Nayak Hospital

Brief Summary

This study is a prospective,randomised double blinded controlled study evaluating the early respiratory muscle strength recovery by ultrasonographic evaluation following reversal with neostigmine versus sugammadex in Lok Nayak hospital, New Delhi for 12 months.The secondary outcome will be to evaluate the difference in thickness fraction of internal oblique from baseline to 30 minutes post extubaction , to evaluate the difference in diaphragmatic thickness fraction from baseline to 5 and 30 minutes post extubation and to evaluate the time to train of four ratio recovery to 0.9 .

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2024-01-16
• Study Start: 2024-01-27

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

1.Patients 18 to 65 years of age 2.Patients having ASA physical status I and II 3.BMI < 30 Kg/m2.

Exclusion Criteria

1.Pregnant or breastfeeding women 2.Patient with history of allergy to Sugammadex, Neostigmine or Vecuronium 3.Patient with renal or hepatic impairment 4.Patient with known neuromuscular disease 5.Suspected difficult airway 6.Patients in whom satisfactory ultrasound imaging or space for placement of the ultrasonic probe will be difficult.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1.Mean change in TFIO from baseline to 5 minutes post extubation	At the time of induction & 5 minutes & 30 minutes after extubation

Secondary Outcome Measures

Name	Time	Method
1. Mean change in thickness fraction of internal oblique from baseline to 30 minutes post extubation.	2. Mean change in diaphragmatic thickness fraction from baseline to 5 and 30 minutes post extubation

Trial Locations

Locations (1)

Maulana Azad Medical College and associated hospitals; 🇮🇳 Central, DELHI, India

Maulana Azad Medical College and associated hospitals

🇮🇳Central, DELHI, India

Dr Priyanka

Principal investigator

9315273920

priyamaurya930@gmail.com