Effect of Granulocyte colony stimulating factor (G-CSF) on in-vitro fertilization (IVF) results
Phase 3
- Conditions
- female infertility.Female infertility of uterine originN97.2
- Registration Number
- IRCT20230718058835N1
- Lead Sponsor
- Hamedan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Female
- Target Recruitment
- 134
Inclusion Criteria
Age less than 40 years
maximum FSH level of 15 IU/ml
repeated IVF failure
absence of contraindications to receiving G-CSF (active infection, tuberculosis cycle disease, chronic neutropenia, history of malignancy in the past, current malignancy, renal failure, upper respiratory tract infection, congenital fructose intolerance)
absence of any systemic diseases (hypertension, diabetes, antiphospholipid syndrome, lupus, thrombophilia and thyroid diseases)
Exclusion Criteria
Insufficient endometrial thickness (minimum 7 mm on the day of HCG injection)
hypersensitivity to GCSF
diagnosis of Asherman's syndrome
diagnosis of polyps and fibroids by hysteroscopy
refusal to participate in the study
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Chemical pregnancy rate. Timepoint: two weeks after embryo transfer. Method of measurement: serum level of ß-HCG.
- Secondary Outcome Measures
Name Time Method Clinical pregnancy rate. Timepoint: 4-6 weeks after embryo transfer. Method of measurement: Transvaginal ultrasound.