Evaluation of effectiveness of preoperative Dexmedetomidine nebulization vs Lignocaine nebulization on blood pressure and heart rate changes to laryngoscopy and tracheal intubation

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2021/08/035734
• Lead Sponsor: Urvisha Mendpara

Brief Summary

Aim of study is to know efficacy of preoperative Dexmedetomidine nebulization vs Lignocaine nebulization on reducing heart rate and blood pressure in response to laryngoscopy and tracheal intubation

Patients suitable for study as per inclusion and exclusion criteria from SSG hospital will be selected

Demographic details, history, investigation will be assesed and general and systemic examination will be done

Patients will be randomly divided in two groups

One group will be nebulized with Dexmedetomidine 1microgram per kg diluted upto 5ml with 0.9% normal saline 30 min before induction of anesthesia and the other group will be nebulized with 4% Lignocaine 3 milligram per kg 30in before induction of anesthesia

Heart rate, systolic and diastolic blood pressure and mean arterial pressure will be monitored before laryngoscopy , at the time of laryngoscopy and 1min, 3min, 5min and 10 min afterwards

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-22
• Last Update Posted: 2021-11-08

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients posted for elective surgery under general anesthesia requiring endotracheal intubation ASA grade 1 & 2.

Exclusion Criteria

Patient refusal, nasal deformity or nasal blockade, pregnancy , obesity, known or anticipated difficult intubation, requiring more than 2 attempts of intubation or more than 20 sec for laryngoscopy, hypertensive patients, allergic to Dexmedetomidine or Lignocaine.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure in response to laryngoscopy and tracheal intubation	Observe heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure at time of laryngoscopy , 1 min ,3 min, 5 min and 10 min after that

Secondary Outcome Measures

Name	Time	Method
To observe effects on rate pressure product or side effects if any	At time of laryngoscopy, 1min ,3min ,5min and 10 min after that

Trial Locations

Locations (1)

government medical college and SSG hospital vadodara; 🇮🇳 Vadodara, GUJARAT, India

government medical college and SSG hospital vadodara

🇮🇳Vadodara, GUJARAT, India

Dr Urvisha Mendpara

Principal investigator

09328224929

urvishapatel7114@gmail.com