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Clinical Trials/NCT07072975
NCT07072975Not yet recruitingNot Applicable

CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia

Centre Hospitalier Universitaire, Amiens2 sites in 1 country50 target enrollmentStarted: October 1, 2025Last updated:

Trial Snapshot

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
50
Locations
2
Primary Endpoint
Perception Exertion score with CR10

Study Overview

Brief Summary

Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses.

this randomized, controlled, study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.

Hypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Other
Masking
None

Eligibility Criteria

Ages
40 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • from 40 to 60 years
  • follow-up in the pneumology unit of CHU Amiens - Picardie
  • Chronic Obstructive Pulmonary Disease stade II
  • Body mass index from 20 to 30 kg.m-2
  • Tiffeneau index < 70% of predicted value
  • FEV1 from 50 to 80% of predicted values
  • Smoking cessation since at least 1 week
  • Sedentary or physical active
  • Affiliate to social security
  • Written consent

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Perception Exertion score with CR10

Time Frame: day 1

The modified Borg CR10 RPE scale measures exertion on a scale of 0 (no exertion or resting) to 10 (pushing yourself to the max).

Secondary Outcomes

  • Cardiorespiratory responses to exercise(day 1)
  • Cardiorespiratory responses to exercise(day 1)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (2)

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