CPOD Patient's Tolerance of Intermittent Exercise With Inter-exercise Recovery Under Normoxic Hypoxia

Not Applicable

Not yet recruiting

• Conditions: Intermittent Hypoxia; Exercise Recovery; Intermittent Exercise; Rating Exertion Perception; Sleep

• Registration Number: NCT07072975
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Exercise retraining improves the prognosis and quality of life of patients with chronic lung or circulatory diseases. However, exercise intolerance may be caused by excessive ventilatory dmeandry. Exposure to oxygen-replete air reduces this ventilatory overload, improves sleep and enhances responses to exercise. This study examine the impact of the acute manipulation of oxygen availability during inter-exercise recovery period of an intermittent cycling exercise on perceptual responses.

this randomized, controlled, monocenter study include adult patient with COPD. On separate days, 50 patients with COPD completed four sets of 4-min at 85% of VO2peak intercept by 3-min of passive recovery in two randomized between-sets recovery conditions. Rating exertion perception, gaz exchanges, heart rate, sleep quality and nocturnal heart rate variability were assessed.

Hypoxic exposure during inter-repetition recovery phases would reduce the ventilatory load during exercise. What's more, patients would not be forced to perform the sporting gesture in a restricted space or wearing a mask, limiting dyspnea and the perceived difficulty of the effort. Lastly, the induction of hypoxic stress during the re-training session helped to improve patients' sleep.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-07
• Study First Submitted: 2025-07-09
• Study First Submitted QC: 2025-07-09
• Last Update Submitted: 2025-07-09
• Study First Posted: 2025-07-18
• Last Update Posted: 2025-07-18
• Study Start: 2025-08-01
• Primary Completion: 2027-07
• Study Completion: 2027-08-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• from 40 to 60 years
• follow-up in the pneumology unit of CHU Amiens - Picardie
• Chronic Obstructive Pulmonary Disease stade II
• Body mass index from 20 to 30 kg.m-2
• Tiffeneau index < 70% of predicted value
• FEV1 from 50 to 80% of predicted values
• Smoking cessation since at least 1 week
• Sedentary or physical active
• Affiliate to social security
• Written consentement

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Perception Exertion score with CR10	day 1	The modified Borg CR10 RPE scale measures exertion on a scale of 0 (no exertion or resting) to 10 (pushing yourself to the max).

Secondary Outcome Measures

Name	Time	Method
Cardiorespiratory responses to exercise	day 1	Cardiorespiratory responses to exercise is measured with gazeous exchange volumes

Trial Locations

Locations (1)

CHRU Amiens; 🇫🇷 Amiens, France