EFFECTIVENESS OF SINGLE DOSE ORAL DEXAMETHASONE VERSUS MULTIDOSE PREDNISOLONE FOR TREATMENT OF ACUTE EXACERBATIONS OF ASTHMA AMONG CHILDREN ATTENDING THE EMERGENCY DEPARTMENT OF CHILDREN HOSPITAL, ISLAMABAD
- Registration Number
- NCT05850143
- Lead Sponsor
- DR. MOHAMMAD ALI ARIF
- Brief Summary
In this Study i'll compare the effectiveness of two drugs used in acute exacerbation of asthma by their sideffects, complaince and improvement in the PRAM score. The better one would be adapted in our clinical practice.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 192
Inclusion Criteria
- i.Ages 2 to 12years ii. Previous history of asthma as diagnosed by a physician. iii. Presentation with acute exacerbation of asthma with symptoms of cough, wheeze, dyspnoea and oxygen saturation of less than 95% and with PRAM score of more than or equal to 6
Exclusion Criteria
- i.Critical or life-threatening asthma i.e. patient with silent chest, cyanosis, drowsy, unable to verbalize, marked tachycardia and respiratory distress. ii.Known TB exposure iii.Fever more than 39. 5°C iv.Use of corticosteroids in previous 4 weeks v.Significant co-morbid disease: lung, cardiac, immune, liver, endocrine, neurological or psychiatric
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Oral Single dose dexamethsone in acute exacerbation of asthma Dexamethasone - Oral Multidose Prednisolone in acute exacerbation of asthma Prednisolone -
- Primary Outcome Measures
Name Time Method Improvement in PRAM score 4 days PRAM will be evaluated at day 4
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms differentiate dexamethasone and prednisolone in modulating glucocorticoid receptors during pediatric asthma exacerbations?
How does single-dose dexamethasone compare to multi-dose prednisolone in efficacy and safety for pediatric acute asthma exacerbations versus standard corticosteroid regimens?
Which biomarkers predict response to dexamethasone or prednisolone in NCT05850143 pediatric asthma exacerbation treatment outcomes?
What are the adverse event profiles and management strategies for single-dose dexamethasone versus multi-dose prednisolone in pediatric asthma exacerbations?
Are there combination therapies involving dexamethasone or prednisolone that improve outcomes in pediatric acute asthma exacerbations compared to monotherapy?
Trial Locations
- Locations (1)
Asim Nawaz Niazi
🇵🇰Islamabad, Pakistan
Asim Nawaz Niazi🇵🇰Islamabad, Pakistan