NCT01260428Unknown不适用
Arterial Oxygenation During Hypoxia : Effects of an Added Expiratory Resistance
AGIR à Dom1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2011年2月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- SpO2
研究概览
简要总结
Altitude tolerance correlates with the level of oxygenation achieved. The aim of the present study is to investigate whether increased expiratory pressure within the thorax is able to improve oxygenation during hypoxic hypoxia.
详细描述
Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing.
Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max).
FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
SpO2
时间窗: mean over 1 minute
after three minutes of PEEP vs spontaneous breathing
次要结局
- cardiac output(mean over 1 min)
- peripheral HbO2/DeoxyHb(1 min)
- pattern of breathing (fR, VT, PETCO2)(1 min)
研究者
研究点 (1)
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