The Influence of Clonidine on the Thrombozytes of Patients Under Double Anticagulation With ASS and Clopidogrel - an in Vitro Study
试验速览
- 阶段
- 不适用
- 发起方
- 试验地点
- 1
- 主要终点
- Numbers of participants with an activated area under the curve in ASPI test
研究概览
简要总结
Clonidin works as a presynaptic agonist of alpha-sympathomimetic receptors of the brain but also in many other tissues. It is part of balanced anesthesia in general anesthesiology as well as a sedastive agent in intensive care units, but also serves as a third-line agent in many psychiatric diseases including ADHD, schizophrenia and PTSD.
The investigators want to show whether clonidin has an procoagulatoric effect on thrombozytes of patients under double anticoagulaotirc treatment with ASS and clopidogrel. The investigators will use a flowcytometric assay to determine activation of thrombozytes when they come into contact with clonidine in vitro as well as Multiplate analyses to determine activation of thrombozytes, either thrombin.induced aggregation, ADP-induced aggregation or arachidonic acid-induced aggregation of thrombozytes.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective vascular surgical patients with long-term medication (at least 5 days) with ASS and clopidogrel
- •Age above 18 years
排除标准
- •Additional anticoagulatoric treatment woth another inhibitor of platelet aggregation
- •Surgery within the last two weeks
- •Patients with long-term mediaction with omeprazole
- •Patients under hemodialysis
- •Patients with renal insufficiency (creatinine above 1.5mg/dl, urea above 80mg/dl)
- •Patients with hepatic dysfunction (GOT above 30U/I, GPT above 30 U/I, GLDH above 10 U/I)
- •Age under 18 yeary
- •Non-responder to ASS and / or clopidogrel
结局指标
主要结局
Numbers of participants with an activated area under the curve in ASPI test
时间窗: 30 minutes
Blood of patients under ASS and clopidogrel will show an activated platelet aggregation due to titrated clonidine in ASPI test, i.e. an activated area under the curve in Multiplate analysis.
次要结局
- Numbers of participants with an activated area under the curve in TRAP test and ADP test(30 minutes)