Effects of various doses of statin therapy on the endothelial function in young adults with familial hypercholesterolemia

Completed

• Conditions: Familial hypercholesterolemia (FH); Nutritional, Metabolic, Endocrine; Disorders of lipoprotein metabolism and other lipidaemias

• Registration Number: ISRCTN47683043
• Lead Sponsor: Academic Medical Center (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-02-14
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Healthy heterozygous FH patients aged >18 years with a documented LDL receptor mutation and LDL cholesterol level above the 95th percentile for age and gender. Or LDL cholesterol above 95th percentile and a positive family history for FH or premature CAD.

Exclusion Criteria

1. Females who are pregnant or intend to become pregnant
2. Hypersensitivity or contraindication to simvastatin
3. Excessive alcohol consumption, smoking or drug abuse

Study & Design

• Study Type: Interventional
• Study Design: Not specified