CTRI/2011/08/001960
Completed
未知
Short term efficacy of electroconvulsive therapy in treatment resistant schizophrenia
Government Medical College and Hospital Chandigarh0 sites30 target enrollmentTBD
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Health Condition 1: null- SchizophreniaHealth Condition 2: F20- Schizophrenia
- Sponsor
- Government Medical College and Hospital Chandigarh
- Enrollment
- 30
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Patients in the age group of 16 to 65 years. 2\. Patients suffering from schizophrenia as per ICD 10\.
- •3\. Patients who fulfilled the criteria for TRS. For the purpose of the study, TRS was defined according to the modified Kane et.al. criteria, which defines TRS as:
- •a) At least two prior drug trials of at least 4\-6 weeks duration at 400\-600 mg of chlorpromazine (or equivalent) without significant clinical improvement.
- •b) Persistent psychotic symptoms defined as a score of 45 on 18 item scale of BPRS and score of 4 (moderate) on at least two items of positive symptoms.
- •c) The duration of illness should be at least one year.
- •4\. Patients who were accompanied by reliable informants.
- •5\. Patients and informants who were willing to participate in the study and who were ready to give consent for ECT and anesthesia.
Exclusion Criteria
- •1\. Patients who had associated medical problems, which could affect the course of illness as well as their fitness for general anesthesia.
- •2\. Patients of co\-morbid substance dependence except nicotine dependence.
- •3\. Patients who had received ECT in the past one\-year.
- •4\. Patients who had received at least 4 ECT?s in the past without any significant improvement.
- •5\. Patients who were intellectually deficient. 6\. Patients having schizoaffective disorder.
Outcomes
Primary Outcomes
Not specified
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