A Prospective Comparison of Cardiac Troponin T and Troponin I in the Diagnosis of Myocardial Infarction
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Herlev Hospital
- Enrollment
- 300
- Locations
- 2
- Primary Endpoint
- Specificity for MI
Study Overview
Brief Summary
The rising number of patients with chest pain without myocardial infarction has made accurate diagnosis important. Unnecessary invasive coronary angiographies are increasingly prevalent. These are both costly and lead to rare but serious adverse events. Recent studies suggest cardiac Troponin I is more cardiac specific than cardiac Troponin T. In this study we will investigate whether using cardiac Troponin I lead to fewer unnecessary procedures in clinical practice (i.e. invasive coronary angiography and non-invasive tests)
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Admitted to either Herlev-Gentofte or Amager-Hvidovre Hospital
- •Clinically suspected of NSTEMI
- •Referred to invasive coronary angiography (ICA)
- •Recieved at least one measurement of either troponin
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Specificity for MI
Time Frame: 0
The difference in specificity of cardiac Troponin and I in detecting patients with significant CAD. The specificity will be defined as the proportion of patients with no significant CAD on ICA correctly identified as low-risk patients and not referred to ICA upon the review by the senior cardiologists
Cost-effectiveness
Time Frame: 0
The cost-effectiveness of using cardiac Troponin T compared to cardiac Troponin I. This will be defined by the number of patients sent to ICA and the associated costs of this.
Secondary Outcomes
- Sensitivity for MI(0)
- Elevated troponin without CAD(0)
- Number of MIs(0)
- PPV and NPV(0)
Investigators
Rasmus Bo Hasselbalch
MD
Herlev Hospital