Genetics of Schizophrenia

• Conditions: Schizophrenia

• Registration Number: NCT00619437
• Lead Sponsor: Sheba Medical Center

Brief Summary

Genetic etiology in schizophrenia is widely accepted. However, many chromosomal sites were shown to characterize the families of patients with schizophrenia. This is probably due to the high genetic heterogenity of this illness. Thus, it is important to investigate the genetic factor in relatively genetically homogenous populations. Many studies have indicate that Ashkenazy Jews show relative gentic homogenity. Indeed, the genes responsible for most Mendelian disorders of Jewish peoples have been identified. The study will apply genome-wide mutation screening methods to identify candidate allells in subjects of Ashkenazi Jewish ancestry with multiplex schizophrenia.

Detailed Description

Not available

Study Timeline

• Status Verified: 2008-02
• Study First Submitted: 2008-02-10
• Study First Submitted QC: 2008-02-10
• Last Update Submitted: 2008-02-10
• Study First Posted: 2008-02-21
• Last Update Posted: 2008-02-21
• Study Start: 2008-04
• Study Completion: 2009-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Age 18+;
2. Meet DSM-IV criteria for Schizophrenia;
3. At least one first-degree relative who Meet DSM-IV criteria for Schizophrenia;
4. Can sign the informed consent form.

Exclusion Criteria

1. Patients suffering from terminal or incurabale disease;
2. Minors, incompetents

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Sheba Medical Center; 🇮🇱 Tel Hashomer, Israel