Exercise Dose and Insulin Sensitivity in Obese Children
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Obesity
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Enrollment
- 222
- Locations
- 1
- Primary Endpoint
- Insulin area under the curve (oral glucose tolerance test)
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
The study is a behavioral clinical trial of aerobic exercise to determine dose-response effects on risk for type 2 diabetes, fatness, fitness, blood cholesterol levels, and other cardiovascular risk factors in overweight elementary schoolchildren.
The hypothesis is that the more exercise a child does, the more benefit he or she will gain in reducing the risk of diabetes and other cardiovascular diseases.
An ancillary study examined effects on cognition and achievement.
Detailed Description
The study is a behavioral clinical trial of aerobic exercise to determine dose-response effects on insulin response to the oral glucose tolerance test, body composition, fitness, lipid profile, inflammation and other metabolic syndrome components in overweight elementary schoolchildren. Blinded psychological assessments of cognition and achievement were obtained.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Overweight, sedentary children
- •Black or white race
- •Attending specific schools in Augusta, GA area from which this study is recruiting
Exclusion Criteria
- •Unable to participate in testing or vigorous exercise program
- •Taking medication that would affect study results
- •Sibling enrolled in project
Outcomes
Primary Outcomes
Insulin area under the curve (oral glucose tolerance test)
Time Frame: 10-15 weeks
Body composition (% body fat, visceral fat)
Time Frame: 10-15 weeks
Aerobic fitness
Time Frame: 10-15 weeks
Cognition (Executive function)
Time Frame: 10-15 weeks
Secondary Outcomes
- Glucose (oral glucose tolerance test)(10-15 weeks)
- Inflammation (C-reactive protein, fibrinogen)(10-15 weeks)
- Lipid profile(10-15 weeks)
- Blood pressure(10-15 weeks)
- Academic achievement(10-15 weeks)