Evaluation of hand microvessel blood flow changes after transient obstruction in patients with infections associated with organ dysfunctions

• Conditions: Sepsis; Ischemia; Biomarkers; Genetics; Microcirculation; Vascular Resistance

• Registration Number: RBR-35tv9ft
• Lead Sponsor: Complexo hospital de Clínicas da Universidade Federal do Paraná

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-06
• Last Update Posted: 29 May 2023
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Adult patients aged greater than or equal to 18 years admitted consecutively to intensive care units with a diagnosis of sepsis and septic shock; patients previously admitted for other causes within 24 hours of onset.

Exclusion Criteria

Severe hepatopathy (Child-Pugh class C); Severe coagulopathy (Platelets less than 20,000 and/or activated partial thromboplastin time (APTT) more than 70 seconds and or international normalized ratio (INR) greater than 2); Presence of severe active bleeding; Infective endocarditis; Inaccessible perfusion assessment (severe hypothermia; Raynaud's syndrome, peripheral arterial occlusive disease); Pregnancy; Refusal of the patient to participate in the study.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of the differences in ischemic microvascular reserve rates between survivors and nonsurvivors of patients with sepsis determined by varying peak perfusion index delta values (%).