Development of a prediction tool for kidney injury in patients with respiratory disorder on different ventilation techniques.

Not Applicable

Conditions: Health Condition 1: N178- Other acute kidney failure

Registration Number: CTRI/2024/01/061610

Lead Sponsor: Faculty SEED grant- Manipal Academy of Higher Education

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

ARDS patients who receive either oxygen therapy, non-invasive ventilation or invasive ventilation (endotracheal or tracheostomy) within the first 24 hours of diagnosis.

Patients should have an acute decrease in ratio of partial pressure of arterial

oxygen to fraction of inspired oxygen of less than or equal to 200.

Evidence of bilateral pulmonary infiltrates on a chest radiograph consistent with

ARDS

C-reactive protein levels less than 50mg per L

Bedside ultrasonogram confirming normal kidneys on admission.

Exclusion Criteria

No past history of kidney injury, obstructive nephropathy, pyelonephritis, circulatory

shock requiring vasopressors, cardio-respiratory arrest or IV contrast which can

contribute to AKI.

No history of nephrotoxic drugs for the past 2 weeks

Patients with any mode of ventilation less than 24 hours received from outside hospital.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of acute kidney injury among spontaneous or controlled ventilation patients with ARDSTimepoint: Blood and urine samples will be collected within 12-24 hours of time of admission

Secondary Outcome Measures

Name	Time	Method
To determine the feasibility of using the inflammatory and urinary biomarkers for predicting acute kidney injury in moderate to severe ARDS patients who are on spontaneous or controlled ventilation and develop a prediction toolTimepoint: 12-24 hours of admission