DRKS00030597
Recruiting
Not Applicable
Metabolic health in neurodegenerative diseases - implications of metabolic characteristics and gut microbiome - NeuroBiom
Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn0 sites100 target enrollmentFebruary 7, 2023
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- G20
- Sponsor
- Klinik und Poliklinik für Neurologie, Universitätsklinikum Bonn
- Enrollment
- 100
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •BMI 18,5\-39,9 kg/m²
- •Non\-smoker (for at least 3 months)
- •written declaration of consent for participation in the study.
- •Diagnosis Parkinson disease or Alzheimer disease
- •PD based on clinical diagnosis according to Brain Bank criteria(Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease. A clinico\-pathological study of 100 cases. JNNP 1992;55:181\-184\.)
- •Hoehn \& Yahr stadium 1\-3
- •Clinical and biomarker\-based diagnosis with Alzheimer's pathology based on typical CSF findings
- •Mixed dementia with a vascular component (up to Fazekas II) is permitted.
Exclusion Criteria
- •Taking medications that affect glucose metabolism
- •chronic hepatic diseases, gastrointestinal diseases, chronic inflammatory diseases or other severe diseases
- •antibiotic therapy 3 weeks before the start of the study
- •Planned lifestyle changes
- •regular intake of supplements
- •drug abuse
- •participation in another clinical trial simultaneously/in the last 30 days
- •Atypical PD syndromes
- •severe motor fluctuations
- •Dementia of unclear origin
Outcomes
Primary Outcomes
Not specified
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