Identification of Early Semantic Markers of Alzheimer's Disease by Using Eye Tracking in Reading Neutral and Predictable Sentences
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Eye tracking
研究概览
简要总结
The objective of this study is to identify early and accurate semantics markers of Alzheimer's disease (AD) by using two types of methods. First, the investigator will evaluate semantic processing of patients with AD or related disorders which will be compared to age matched controls by taking neuropsychological tests. Then, the investigator will analyze the effect of contextual word predictability on eye movements in reading sentences with the help of the same participants by using an eye tracker. Both of these methods will be used twice with a time interval of 6 months.
详细描述
Scientific background:
Identifying Alzheimer's disease (AD) as early as possible should enable to propose a re-education platform that would fit the early stage of neuronal loss in this pathology. Neuropsychological evaluations are currently one of the main tools for the early screening of AD. Among the tests proposed during those evaluations, the investigator find the Isaacs Set Test which evaluates the early degradation of semantic memory. Whereas eyes movement behavior during reading is sensitive to semantics factors and allows collecting accurate measurements (as precisely as one millisecond), no study has yet used this technique to precisely identify the precocious semantics troubles of AD.
Goal:
The objective of this study is to identify early and accurate markers of AD by associating semantic neuropsychological assessments and eye tracking during sentences reading.
Method:
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Pour le bras A :
- •Inclusion criteria
- •Mother tongue french participants
- •Participants with a level of education = or > to Junior Secondary School Diploma
- •Participants with a normal or corrected vision
- •Participants with good score at the neuro visual assessments (> or = to 15 at the "detection test" ; > or = to 16 at the "degraded letters" test
- •Participants suffering from Alzheimer's or related disorders disease (ICD-10 criteria)
- •Participants with an MMSE's score between 20 and 27
- •Participants must sign the informed consent
- •Participants must be affiliated to the social insurance. Non-inclusion criteria
- •Impossibility to realize the experiment because of a blurred vision
- •History of neurological or psychiatric disease, of alcoholism and of brain injury
- •Participants under trusteeship, guardianship or placed under judicial protection
- •Persons deprived of their liberty
- •Pour le bras B :
- •Inclusion criteria
- •Mother tongue french participants
- •Participants with a level of education = or > to Junior Secondary School Diploma
- •Participants with a normal or corrected vision
- •Participants with no global cognitive impairment with a MMSE's score > or = to 28 and with no difficulty to repeat and recall the 3 words
- •Participants with good score at the neuro visual assessments (> or = to 15 at the "detection test" ; > or = to 16 at the "degraded letters" test
- •Participants must sign the informed consent
- •Participants must be affiliated to the social insurance. Non-inclusion criteria
- •Impossibility to realize the experiment because of a blurred vision
- •Prescription of psychotropic medication during the week preceding the experiment
- •History of neurological or psychiatric disease, of alcoholism and of brain injury
- •Evidence of cognitive decline
- •Decline in the day-to-day operations
- •Participants under trusteeship, guardianship or placed under judicial protection
- •Persons deprived of their liberty
排除标准
- 未提供
结局指标
主要结局
Eye tracking
时间窗: at six months
Eye tracking (More specifically, the investigator will evaluate gaze duration on target words included in sentences while participant's eye movements will be recorded with the Eye link 1000 remote. Gaze duration is the sum of all fixations on a word prior to moving to another word)
次要结局
- the percentage of refixation done on the target word(at six months)
- the first fixation duration in the target word(at six months)
- the percentage of regressive saccade on the target word and the total viewing time(at six months)
- Neuropsychological tests scores(at six months)
- the single fixation duration(at six months)
- The probability that the eyes skip the target word(at six months)
- the initial landing position of the eye in the target word (in letters)(at six months)