临床试验/NCT01977131

NCT01977131已完成1 期

Phase 1 Study of Autologous Bone Marrow Stromal Cells With Modification by Hepatocyte Growth Factor to Treat Silicosis

Wei Yu0 个研究点目标入组 10 人开始时间: 2010年6月1日最近更新: 2013年11月25日

适应症

试验速览

阶段: 1 期
状态: 已完成
发起方
入组人数: 10
主要终点: Absence of lung deficits during the procedure and/or in the 6 months follow-up

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

The aim of this study was to analyze the safety, pulmonary function, and imaging changes of patients with silicosis treated with autologous bone marrow stromal cells with modification by hepatocyte growth factor.

研究设计

研究类型: Interventional
分配方式: Na
干预模型: Single Group
主要目的: Treatment
盲法: Single (Participant)

入排标准

年龄范围: 18 Years 至 50 Years（Adult）
性别: All
接受健康志愿者: 否

入选标准

•age between 18-50, chronic and accelerated silicosis, characterized with a fibrotic increase in the last two years, FEV1 <60% and > 40%, FVC > 60% and SaO2 >90%

排除标准

•smoking, active tuberculosis or other infections, cancer, auto-immune disorders, hematological, hepatic or cardiac diseases, and pregnancy

结局指标

主要结局

Absence of lung deficits during the procedure and/or in the 6 months follow-up

时间窗: 6 months

次要结局

Improvement of pulmonary deficits(1 year)

研究者

发起方

Wei Yu

申办方类型

Other

责任方

Sponsor Investigator

主要研究者

Wei Yu

Doctor

Guangzhou Municipal Twelfth People's Hospital

相似试验

已完成

1 期

Safety of Stem Cells Intrabronchial Instillation for SilicosisChronic and Accelerated Silicosis

NCT01239862Universidade Federal do Rio de Janeiro5

撤回

1 期

Safety and Efficacy of Autologous Stem Cell Therapy in Chronic StrokeCerebrovascular Accident

NCT02065778Neurogen Brain and Spine Institute

终止

1 期

Autologous/Allogeneic Progenitor Stem Cell Therapy for Congestive Heart FailureHeart Failure, Congestive

NCT00128258Amit, Patel N, M.D.10

Unknown

1 期

Stem Cell Transplantation for the Treatment of Knee OsteoarthritisKnee Osteoarthritis

NCT00550524Tehran University of Medical Sciences5

Unknown

1 期

Clinical Trial of Use of Autologous Bone Marrow Stem Cells Seeded on Porous Tricalcium Phosphate Matrix and Demineralized Bone Matrix in Patients With OsteonecrosisOsteonecrosis of Jaw

NCT02566681Red de Terapia Celular10