Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue

Not Applicable

Completed

• Conditions: Metabolic Syndrome; Obesity; Insulin Sensitivity

• Registration Number: NCT00774488
• Lead Sponsor: German Institute of Human Nutrition

Brief Summary

This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in subcutaneous adipose tissue.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-01
• Primary Completion: 2007-07
• Study Completion: 2007-07
• Status Verified: 2008-10
• Study First Submitted: 2008-10-16
• Study First Submitted QC: 2008-10-16
• Last Update Submitted: 2008-10-16
• Study First Posted: 2008-10-17
• Last Update Posted: 2008-10-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 17

Inclusion Criteria

• BMI > 28
• Healthy subjects
• Normal glucose tolerance

Exclusion Criteria

• Diabetes,IFG, IGT
• Chronical-inflammatory diseases
• Hb < 12g/dl
• Elevation in liver enzymes or creatinin concentrations
• Great weight changes within last 12 months
• Any cancer diagnosis in last 10 years

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Changes in gene expression of subcutaneous adipose tissue with microarray analysis	3 years

Secondary Outcome Measures

Name	Time	Method
Analysis of inflammatory marker (blood levels and gene expression), Activity of 11beta HSD and 11-beta HSD mRNA in adipose tissue, etc.	3 years