NCT00774488已完成不适用
Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 17
- 主要终点
- Changes in gene expression of subcutaneous adipose tissue with microarray analysis
研究概览
简要总结
This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in subcutaneous adipose tissue.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •BMI > 28
- •Healthy subjects
- •Normal glucose tolerance
排除标准
- •Diabetes,IFG, IGT
- •Chronical-inflammatory diseases
- •Hb < 12g/dl
- •Elevation in liver enzymes or creatinin concentrations
- •Great weight changes within last 12 months
- •Any cancer diagnosis in last 10 years
结局指标
主要结局
Changes in gene expression of subcutaneous adipose tissue with microarray analysis
时间窗: 3 years
次要结局
- Analysis of inflammatory marker (blood levels and gene expression), Activity of 11beta HSD and 11-beta HSD mRNA in adipose tissue, etc.(3 years)
研究者
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