Effects of Liothyronine In The Prevention of Electroshock-Induced Cognitive Side Effects

Not Applicable

• Conditions: Condition 1: bipolar disorder. Condition 2: depressive disorder.; Bipolar affective disorder; depressive episode

• Registration Number: IRCT2015081823673N1
• Lead Sponsor: Kashan University of Medical Science Vise Chancellor for Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

inclusion criteria: men and women 18 to 45 years old with mood disorder diagnosis(major depressive disorder or bipolar disorder)based on DSM4TR criteria; candidate of ECT; without sensitivity to liothyronine; negative pregnancy test before treatment initiation; using safe contraception during the study.
exclusion criteria: unstable cardiovascular disease; history of myocardial infarction in past 3 months; current unstable angina; untreated endocrine disorders; uncontrolled hypertention; structural brain anomaly; cerebral infarct or hemorrhage in past 1 month; unstable or bleeding vascular anneurism; severe respiratory disorders that are contraindications of general anesthesia; decompensating heart problems; heart vulvular disorders; brain space occupying lesions leading to increased intracranial pressure; pregnancy; addiction( except smoking) during the study; ECT treatment in past 6 months; allergic reaction to liothyronine; mental retardation; delirium, dementia or other amnestic disorders; occurrence of ECT-induced delirium during the study; lithium administration during the study.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Memory. Timepoint: before first ECT session, before 4th ECT session, 1 month after last ECT session. Method of measurement: wechsler memory scale.

Secondary Outcome Measures

Name	Time	Method
Altered thyroid function. Timepoint: before 4th ECT session and 1 month after last ECT session. Method of measurement: thyroid function blood test.