NL-OMON54874
Recruiting
Not Applicable
Effects of COVID-19-infection on movement and tissue characteristics of the diaphragm visualized by magnetic resonance imaging: a proof-of-concept study - Diaphragm MRI
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Vrije Universiteit Medisch Centrum
- Enrollment
- 40
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Invasive mechanical ventilation \> 72 hours during current hospital admission
- •(only patients)
- •Discharged from the ICU \<\= 14 days ago (only patients)
- •Admitted for COVID\-19\-infection (n \= 10\)
- •Currently negative COVID\-19 PCR test (only previously infected subjects)
- •Age 50\-70 years (only healthy volunteers)
- •Signed informed consent
- •Age \>\= 18 years (only patients)
Exclusion Criteria
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •Known history of:
- •o Diaphragmatic injury or weakness
- •o COPD (GOLD IV)
- •o Neuromuscular disease (including pathology of the n. phrenicus)
- •o Connective tissue disease
- •o Chronic use of corticosteroids (\>7\.5 mg/day for at least 3 months before
- •hospital admission)
- •o \>10% weight loss within last 6 months (before hospital admission)
Outcomes
Primary Outcomes
Not specified
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