Associations of Vitamin D Deficiency and Vitamin D Receptor Polymorphisms With the Risk of Primary Open-angle Glaucoma
Completed
- Conditions
- Vitamin D DeficiencyPrimary Open- Angle Glaucoma
- Registration Number
- NCT02539745
- Lead Sponsor
- Lv Yingjuan
- Brief Summary
This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele and vitamin D deficiency is an important factor in the development of glaucoma. Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by enzyme-linked immunoabsorbent assay. Vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
Inclusion Criteria
- intraocular pressure greater than 22 mmHg with two or more medications
- wide anterior chamber angle
- glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect)
- visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry
Exclusion Criteria
- the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma
- high myopia
- macular degeneration
- other ocular diseases
- a known history of systemic diseases and administration of vitamin D3 or other analog
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum levels of 1a, 25-Dihydroxyvitamin D3 1 day visit
- Secondary Outcome Measures
Name Time Method gene polymorphisms of vitamin D receptor 1 day visit
Trial Locations
- Locations (1)
Tianjin Medical University Eye Hospital
🇨🇳Tianjin, Tianjin, China
Tianjin Medical University Eye Hospital🇨🇳Tianjin, Tianjin, China