Evaluation of the Relationship Between Menopause and Periodontal Health With Biochemical and Microbiological Parameters
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 148
- 试验地点
- 1
- 主要终点
- Periodontitis
研究概览
简要总结
Menopause is characterized by major physiological and concomitant psychological changes. The study aimed to evaluate the association between oral health parameters, bone mineral density (BMD) and physiological or psychological symptoms in post-menopausal women (PMW), compared with regularly menstruating women (RMW). Inflammatory biomarker levels in gingival crevicular fluid, saliva, serum and determination of microbial niches in subgingival plaque samples were further aimed. The participants were asked to complete the Women's Health Questionnaire to measure emotional and physical well-being.
A total of 148 women (PMW, n=76,RMW, n=72) received a comprehensive medical assessment and a full-mouth oral examination. The corresponding bone mineral density (BMD) and body mass indices (BMI) were obtained from their medical records.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Being 35-65 years of age
- •Having history of spontaneous amenorrhea for the last 12 months for PMW.
- •Lack of irregularity in menstrual cycles during the past 12 months for RMPW.
- •Possessing at least 10 natural teeth without any prosthetic restoration
排除标准
- •History of antibiotics use in last 3 months
- •Ongoing cancer therapy
- •Presence of oral ulcers or acute infectious disease
- •Presence of diabetes mellitus
结局指标
主要结局
Periodontitis
时间窗: 1 month
Interdental attachment loss is detectable at ≥2 non-adjacent teeth, or buccal/oral attachment loss ≥3 mm with pocketing \>3 mm at ≥2 adjacent teeth were present.
次要结局
未报告次要终点