Expression and the Clinical Significance of TIM-3 on Lymphocytes During Sepsis
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- TIM-3 expression on CD4+, CD8+ T cells and CD14+ monocytes
研究概览
简要总结
The current project was designed to examine the express TIM-3 on lymphocytes and monocytes and its role in immunosuppression during sepsis.
详细描述
Immunosuppression is the leading cause of death in septic patients.Lymphocyte apoptosis has been recognized as an important step in the pathogenesis of sepsis. Previous studies indicated that T cell immunoglobulin and mucin protein 3 (TIM-3) is a type I cell surface protein and was identified as a marker of lymphocyte dysfunction. The current project was designed to examine the express TIM-3 on lymphocytes and monocytes and its further role in immunosuppression during sepsis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •patients with severe sepsis
- •patients undergo invasive spine surgery
- •healthy volunteers
排除标准
- •patients with immunodeficient diseases
- •patients who accept glucocorticoid or immunosuppressant
- •patients with an age older than 18 years
- •patients providing the informed consent
结局指标
主要结局
TIM-3 expression on CD4+, CD8+ T cells and CD14+ monocytes
时间窗: within 24h after recruitment
TIM-3 level on T cells was compared between different populations.
次要结局
- 28-day mortality(28 days after diagnosis of sepsis)
研究者
Xiaoming Deng
professor and chief
Changhai Hospital