JPRN-UMIN000026331尚未招募未知
An open-label, prospective randomized trial to assess the non-inferiority of diuretic effect of tolvaptan as an alternative agent to loop diuretics in chronic heart failure. - The effectiveness of tolvaptan as an alternative agent to loop diuretics in heart failure.
Department of Cardio-Renal Medicine and Hypertension, Graduate School of Medical Sciences, Nagoya City University, Japan0 个研究点目标入组 200 人开始时间: 2017年3月1日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1. Patients who have already received tolvaptan therapy. Patients who are more than 80 years and have difficulty in complain thirst. 2. Patients with renal dysfunction having an estimated glomerular filtration rate 30mL or less /min/1.73m2 and/or requiring hemodialysis. 3. Patients with liver dysfunction which is defined as an increase threefold in aspartate aminotransferase and/or alanine aminotransferase compared to the upper limit of normal range. 4. Patients with percutaneous coronary intervention or open heart surgery within the past 3 months. 5. Patients under the pacing therapy using implantable cardiac pacemaker, cardiac resynchronization therapy device, or implantable cardiac defibrillator. 6. Patients with type 1 diabetes mellitus. 7. Patients with endocrine diseases such as thyroid dysfunction, or adrenal dysfunction which may have an effect on balance of body fluid. 8. Patients with any serious non-cardiovascular disease including malignancy, which have expected 6 months or less to live. 9. Patients without agreement on enrolment of this trial through written texts.
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