Assessing Neuroinflammation and Oxidative Stress After Cardiac Surgery: Unveiling Molecular Dynamics and Clinical Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Number and type of early complications after surgery
研究概览
简要总结
The prospective observational study delves into the complex relationship between neuroinflammation and oxidative stress in post-cardiac surgery complications, focusing on postoperative cognitive dysfunction.
详细描述
The prospective observational study meticulously examines the interplay between neuroinflammation and oxidative stress in the realm of post-cardiac surgery complications, specifically targeting postoperative cognitive dysfunction. Its primary objective is to comprehensively assess the sustained influence of these intricate processes on cognitive function and overall well-being, extending beyond the immediate aftermath of surgery. The research endeavors to probe deeply into the molecular mechanisms and clinical ramifications associated with neuroinflammation and oxidative stress, centering on their pivotal role in shaping the onset and trajectory of postoperative cognitive dysfunction.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Undergoing cardiosurgical operation
- •Absence of previous neurological disease
- •Signed informed consent document
排除标准
- •Presence of neoplasms
- •Neurological Disease
- •Refusal to participate in the clinical trial
结局指标
主要结局
Number and type of early complications after surgery
时间窗: 1 month
Estimating of postoperative complications
Number and type of postoperative complications
时间窗: 6 months
Estimating of postoperative complications
次要结局
- Estimating biochemical parameters Third biochemical examination(1 hour)
- Estimating biochemical parameters(6 hours)
