Comparison of the efficacy of ondansetron alone versus ondansetron and dexamethasone in the prevention or reduction of post operative nausea and vomiting after elective surgeries under general anaesthesia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- To compare the post operative analgesic effects between ondansetron and ondansetron with dexamethasone
Study Overview
Brief Summary
The study is designed to provide evidence that may guide clinical decision-making in managing PONV, potentially improving patient comfort and recovery outcomes. If the combination therapy proves to be more effective than ondansetron alone, it could become the preferred treatment option for preventing PONV in this patient population. Conversely, if both regimens show similar efficacy, the simpler treatment of ondansetron alone may be sufficient, with implications for reducing treatment costs and minimizing medication-related side effects.
This study seeks to add valuable insights into the optimal management strategies for PONV, contributing to enhanced patient care following elective surgeries
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Masking
- None
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •1.Able to provide informed consent 2.American Society of Anaesthesiologists (ASA) physical status I and II.
Exclusion Criteria
- •Patients with contraindications to either medication Patients requiring emergency surgery or those undergoing surgeries with known high PONV risk Severe cardiorespiratory hepatic renal neurological or endocrinal disease obesity diabetes mellitus.
Outcomes
Primary Outcomes
To compare the post operative analgesic effects between ondansetron and ondansetron with dexamethasone
Time Frame: 2hours 6hours 12hours 24hours
Secondary Outcomes
- To identify any potential predictors of optimal dose selection and see the efficacy of both drugs in full 24 hours(2hours 6hours 12hours 24hours)
Investigators
Dr Juhi Mishra
Varun arjun medical college and rohilkhand hospital