The ENDOCARDITIS AUMC Data Collection : a Matched Cohort Study on Perioperative Coagulation in Conservatively and Surgically Treated Patients With Valvular Dysfunction, With and Without Infective Endocarditis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,000
- 试验地点
- 1
- 主要终点
- Thromboembolic complications
研究概览
简要总结
The investigators will compare patients with and without infective ndocarditis undergoing valve surgery and evaluate factors that may help optimise perioperative care of these high-risk patients.
详细描述
The aim of this study is to examine the differences between patients with and without endocarditis who undergo cardiothoracic (valve) surgery. In addition, the investigators will look at the differences between endocarditis patients who undergo surgery, and those who are treated conservatively. The investigators will look at incidence and degree of perioperative coagulation abnormalities, as well as transfusion and coagulation factor requirements, heparin resistance, bleeding scores, predictive endocarditis mortality scores, vasopressor-inotrope scores, and relate these where possible to the pathogen causing IE. The investigators will also look at perioperative complications, in particular, thromboembolic events and mortality at 30 and 90 days, and at 1 year.
These outcomes may help optimise perioperative care for high-risk endocarditis patients, and in particular those undergoing valve surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients > 18 years
- •Dutch or English speaking
- •All patients with infective endocarditis admitted to Amsterdam UMC in the study period
- •All patients with infective endocarditis scheduled for cardiac valve surgery compared to a matched cohort of patients scheduled for similar surgery due to non-infectious indication in Amsterdam UMC in the same period
排除标准
- •Previous history of coagulation disorders
结局指标
主要结局
Thromboembolic complications
时间窗: up to 1 year
Any thromboembolic complications occuring between surgery and 1 year post operatively (incidence, class and severity)
次要结局
- Incidence of perioperative coagulation abnormalities(First 24 hours after surgery)
- Differences in incidence of pathogens and the relation with disease severity(Up to 30 days)
研究者
Jennifer Breel
Research Coordinator
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)