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临床试验/NCT03007368
NCT03007368已完成不适用

Assessment of Gastric Emptying and Fullness of Different Types of Foods in Mali

Purdue University0 个研究点目标入组 20 人开始时间: 2012年3月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
20
主要终点
Gastric emptying

研究概览

简要总结

As populations become urbanized in Africa, the change to a more Westernized diet has been associated with rise in obesity and related metabolic syndrome diseases. The current study shows that in the West African Sahel, these replacement starchy staple foods have fast gastric emptying compared to traditional sorghum and millet foods; and implies that the latter could be beneficial in lowering glycemic response, providing energy from a meal over a longer time, and providing a satiety effect. Knowledge of this attribute of sorghum and millet foods could be useful to improve their image in West African cities to increase their consumption and to improve markets for local smallholder farmers.

详细描述

As suggested by anecdotal evidence that traditional Malian sorghum and millet foods are filling and provide sustained energy, we hypothesized that gastric emptying rates of sorghum and millet foods are slow, particularly compared to non-traditional starchy foods (white rice, potato, wheat pasta) that are now commonly consumed in urban areas of the West African Sahel. A broader purpose for the study was to understand whether sorghum and millet foods have positive health attributes that can be promoted in urban areas to provide better markets for local farmers.

Two human trials of similar design were conducted approximately one year apart. The carbon 13 (13C)-labelled octanoic acid breath test method was used to measure gastric emptying rate, and subjective pre-test and satiety response questionnaires were used. In the first study, 14 healthy volunteers in Bamako, Mali participated in a crossover design to test eight starchy foods for gastric emptying rate and satiety feelings. The second study with six volunteers was done to correct for endogenous 13C differences in the starch component of the foods.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
盲法
None

入排标准

年龄范围
20 Years 至 50 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Normal body mass index (18 kg/m2 ≤ BMI ≤ 25 kg/m2)

排除标准

  • Under any medication
  • History of any gastrointestinal disease or surgery

结局指标

主要结局

Gastric emptying

时间窗: acute study, 4 hours after consumption of test food

Breath test was performed using 13C-octanoic acid mixed into test meals

次要结局

  • Appetitive response(acute study, 4 hours after consumption of test food)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Bruce R. Hamaker

Professor

Purdue University

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