Phase I-II Prospective Trial, Multicenter, Open Label, Exploring the Combination of Trabectedin Plus Radiotherapy in Soft Tissue Sarcoma Patients
Trial Snapshot
- Phase
- Phase 1
- Status
- Recruiting
- Sponsor
- Enrollment
- 199
- Locations
- 17
- Primary Endpoint
- Relapse-free survival.
Study Overview
Brief Summary
Phase I-II trial that combines trabectedin plus radiotherapy for tumor reduction response measure in four cohorts of patients:
Cohort A: Patients with diagnosis of non-operable or unresectable or not oncologically recommended metastasectomy of limited to lung metastases soft tissue sarcoma.
Cohort B: Patients with locally advanced resectable Myxoid Liposarcoma. Cohort C: Patients with retroperitoneal and resectable soft tissue sarcoma (liposarcoma and leiomyosarcoma).
Cohort D (Phase II only): Patients with well differentiated liposarcoma and G2 dedifferentiated liposarcoma (with less than 30% dedifferentiated component).
Phase I: escalating dose of 1.3 or 1.5 mg/m2. Phase I for cohort C: de-escalating dose of 1.5 or 1.3mg/m2 Radiotherapy for cohort A: 30Gy in 10 fractions (3Gy/fraction). Radiotherapy for cohort B: 45Gy in 25 fractions (1.8Gy/fraction). Radiotherapy for cohort C: 45Gy in 25 fractions (1.8Gy/fraction).
Radiotherapy for cohort D: 45Gy in 25 fractions (1.8Gy/fraction). A translational substudy is developed to analyse different biomarkers predictive value.
Cohorts A and B are closed to recruitment in 2023.
Detailed Description
In this study investigators plan to measure tumor response (RECIST and Choi criteria) when administering trabectedin standard dose or inferior with simultaneous radiotherapy treatment. The hypothesis states that administering trabectedin at 1.3mg/m2 or ≤1.5mg/m2 plus Radiotherapy 30-45Gy shows synergic activity that turns into tumor shrinkage.
A phase I trial (dose escalation -or de-escalation for cohort C- level of 1.3 or 1.5 mg/m2) will provide the proper dose level to perform a phase II trial to measure RECIST and Choi response, progression free survival, overall survival and register safety and quality of life details.
Four cohorts are indicated for this trial:
Cohort A: Patients with diagnosis of non-operable or unresectable or not oncologically recommended metastasectomy of limited to lung metastases soft tissue sarcoma.
Cohort B: Patients with locally advanced resectable Myxoid Liposarcoma, Cohort C:Patients with retroperitoneal and resectable soft tissue sarcoma (liposarcoma and leiomyosarcoma).
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •The patient must sign voluntarily the informed consent form before any study test is conducted that is not part of routine patient care.
- •Aged equal or over
- •Patients must have a diagnostic of Soft Tissue Sarcoma with metastasis limited to lung, and not suitable for metastasectomy or surgery resection or not oncologically recommended metastasectomy.A centralized diagnostic will be performed, the tumor sample must be available and sent prior to inclusion.
- •Disease distribution allows meeting with normal tissue constraints of radiation therapy. Radiation oncologist must confirm this point.
- •Metastatic spread could be present in two organs at maximum (i.e. lungs and pelvic fosa).
- •Those lesions considered for radiation therapy have to be considered as target lesions as well. (i.e. in a patient with nodules in lungs, those lesions selected for radiation therapy have to include at least the target lesions)
- •It is allowed that not all the lesions will be under radiation fields. As a general rule, it will be prioritized to select, as target-irradiating lesions, those with greater increase in size and those largest lesions. It should be discouraged to irradiate pulmonary lesions with infiltration of pleural serosa.
- •Patients must have documentation of disease progression within 6 months prior to study entry.
- •The patient must have been considered eligible for systemic chemotherapy. A maximum of two previous lines for advanced/metastatic disease are allowed as long as trabectedin has not been included.
- •The following histological subtypes can be included:
- •Undifferentiated pleomorphic sarcoma (previously, malignant fibrous histiocytoma) Leiomyosarcoma Angiosarcoma/ epithelial hemangioendothelioma Liposarcoma and its variants (well differentiated, dedifferentiated, myxoid/round cells, pleomorphic).
- •Synovial sarcoma Fibrosarcoma and its variants (epithelial fibrosarcoma/low grade fibromyxoid sarcoma) Hemangiopericytoma/solitary fibroid tumor Neurogenic sarcoma (Malignant peripheral nerve sheath tumor, MPNST) Myxofibrosarcoma Epithelioid Sarcoma Unclassified sarcoma (spindle cell/epithelioid/pleomorphic/myxoid)
- •Measurable disease, according to RECIST V 1.1 criteria
- •Performance status ≤1 (ECOG).
- •Adequate respiratory functions: FEV1 >1L; DLco > 40% (patients with pulmonary target lesions)
- •Adequate bone marrow function (hemoglobin > 10 g/dl, leukocytes ≥ 3.000/mm3, neutrophils ≥ 1.500/mm3, platelets ≥ 100.000/mm3). Patients with plasma creatinine ≤ 1,6 mg/dl, transaminases ≤ 2.5 times the UNL, total bilirubin ≤ UNL, CPK ≤ 2.5 times UNL, alkaline phosphatase ≤ 2.5 times the UNL are acceptable. If the increase of alkaline phosphatase is > 2.5 times the UNL, then the alkaline phosphatase liver fraction and/or GGT must be ≤ UNL.
- •Men or women of child bearing potential should be using an effective method of contraception before entry into the study and throughout the same and for 6 months after ending the study. Women of childbearing potential must have a negative urine pregnancy test before study entry.
- •Normal cardiac function with a LVEF ≥ 50% by echocardiogram or MUGA.
- •It should be performed HBV and HCV serologies prior to inclusion. If HbsAg is positive it is recommended to reject the existence of replicative phase (HbaAg+, DNA VHB+). If these were positives the inclusion is not recommended, remaining at investigators' discretion the preventive treatment with lamivudine. If a potential patient is positive for anti-HCV antibodies, presence of the virus should be ruled out with a qualitative PCR, or the patient should NOT be included in the study (if a qualitative PCR cannot be performed then patient will not be able to enter the study)
- •Patient must have a Central Venous Catheter for treatment
Exclusion Criteria
- •Previous treatment with trabectedin or previous treatment with radiotherapy (except if previous radiotherapy treatment plus planned study radiotherapy treatment allow tissues constrains)
- •Performance status ≥ 2 (ECOG).
- •Plasma bilirubin > UNL.
- •Creatinine > 1.6 mg/dL.
- •History of other neoplastic disease with less than 5 years free of disease with the exception of basal cell carcinoma or in situ cervical cancer adequately treated.
- •Severe COPD or other severe pulmonary diseases.
- •Significant cardiovascular disease (for example, dyspnea > 2 NYHA)
- •Significant systemic diseases grade 3 or higher on the NCI-CTCAE v4.03 scale, that limit patient availability, or according to investigator judgment may contribute significantly to treatment toxicity.
- •Uncontrolled bacterial, mycotic or viral infections.
- •Known positive test for infection by human immunodeficiency virus (HIV).
- •Women who are pregnant or breast-feeding.
- •Psychological, familial, social or geographic circumstances that limit the patient"s ability to comply with the protocol or informed consent.
- •Patients participating in another clinical trial or receiving any other investigational product
- •Patients who had participated in another clinical trial and/or had received any other investigational product in the last 30 days prior to inclusion.
- •Histologies other than those described in inclusion criteria.
- •Cohort B: ML
- •Inclusion criteria:
- •The patient must sign voluntarily the informed consent form before any study test is conducted that is not part of routine patient care.
- •Age ≥18 years old.
- •Pathological diagnosis of Myxoid Liposarcoma, deep located and more than 5 cm or superficial more than 10 cm. A centralized diagnostic will be performed to confirm that the patient can be included in the study.
- •Tumor must be resectable and without evidence of regional or distal spread after adequate staging procedure. Tumor must be located in limbs or superficial trunk wall.
- •Disease distribution allows meeting with normal tissue constraints of radiation therapy. Radiation oncologist must confirm this point.
- •Measurable disease, according to RECIST V 1.1 criteria
- •Performance status 0-1 (ECOG).
- •Adequate bone marrow function (hemoglobin > 10 g/dL, leukocytes ≥ 3.000/mm3, neutrophils ≥ 1.500/mm3, platelets ≥ 100.000/mm3). Patients with plasma creatinine ≤ 1,6 mg/dL, transaminases ≤ 2.5 times the UNL, total bilirubin ≤ UNL, CPK ≤ 2.5 times UNL, alkaline phosphatase ≤ 2.5 times the UNL are acceptable. If the increase of alkaline phosphatase is > 2.5 times the UNL, then the alkaline phosphatase liver fraction and/or GGT must be ≤ UNL.
- •Men or women of child bearing potential should be using an effective method of contraception before entry into the study and throughout the same and for 6 months after ending the study. Women of childbearing potential must have a negative urine pregnancy test before study entry.
- •Normal cardiac function with a LVEF ≥ 50% by echocardiogram or MUGA.
- •It should be performed HBV and HCV serologies prior to inclusion. If HbsAg is positive it is recommended to reject the existence of replicative phase (HbaAg+, DNA HBV+). If these were positives the inclusion is not recommended, remaining at investigators' discretion the preventive treatment with lamivudine. If a potential patient is positive for anti-HCV antibodies, presence of the virus should be ruled out with a qualitative PCR, or the patient should NOT be included in the study (if a qualitative PCR cannot be performed then patient will not be able to enter the study).
- •Patient may have had one previous chemotherapy line.
- •Patient must have a Central Venous Catheter for treatment.
- •Exclusion criteria:
- •Unresectable tumors (with limb sparing surgery)
- •More than one previous chemotherapy treatment for local disease including trabectedin.
- •Radiotherapy involving the tumoral bed.
- •Performance status ≥ 2 (ECOG).
- •Presence of metastases or lymph node involvement by the tumor.
- •Location other than limb or superficial trunk wall.
- •Plasma bilirubin > UNL.
- •Creatinine > 1.6 mg/dL.
- •History of other neoplastic disease with less than 5 years free of disease with the exception of basal cell carcinoma or in situ cervical cancer adequately treated.
- •Significant cardiovascular disease (for example, dyspnea > 2 NYHA)
- •Significant systemic diseases grade 3 or higher on the NCI-CTCAE v4.03 scale, that limit patient availability, or according to investigator judgment may contribute significantly to treatment toxicity.
- •Uncontrolled bacterial, mycotic or viral infections.
- •Known positive test for infection by human immunodeficiency virus (HIV).
- •Women who are pregnant or breast-feeding.
- •Psychological, familial, social or geographic circumstances that limit the patient"s ability to comply with the protocol or informed consent.
- •Patients who had participated in another clinical trial and/or had received any other investigational product in the last 30 days prior to inclusion.
- •Cohorts C and D: Retroperitoneum sarcoma
- •Inclusion criteria:
- •The patient must voluntarily sign the informed consent form before performing any study-specific test that is not part of the patient's usual care.
- +31 more not shown
Arms & Interventions
Trabectedin+Radiotherapy
Trabectedin 1.3 or 1.5mg/m2 and radiotherapy 30Gy or 45Gy.
Intervention: Trabectedin (Drug)
Trabectedin+Radiotherapy
Trabectedin 1.3 or 1.5mg/m2 and radiotherapy 30Gy or 45Gy.
Intervention: Radiotherapy (Radiation)
Outcomes
Primary Outcomes
Relapse-free survival.
Time Frame: 5 years.
In cohort D to improve 5-year relapse-free survival (RFS), decreasing the 5-year relapse percentage from 30% to 10% in patients with well differentiated liposarcoma with cellular component and dedifferentiated G2 retroperitoneal resected liposarcoma (20% increase in RFS).
Tumor size
Time Frame: every 6 weeks for 24 months
Image tumor assessment: RECIST response for the combination of trabectedin plus radiation therapy in cohorts A and B. CHOI response for the combination of trabectedin plus radiation therapy in cohort C.
Secondary Outcomes
- Predictive and prognostic biomarker(Baseline and week 11 (at surgery))
- Number of months alive(24 months)
- Tumor size(every 6 weeks during 24 months (cohort A) or every 4months during 36 months (cohort B and C))
- relapse free survival (RFS) at 3 years (cohorts C and D)(After 3 year since last patient treatment initiation)
- Number of months without progression(24 months)
- Overall response rate (ORR)(every 6 weeks during 24 months)
- Number and grade of adverse events(every 21 days until 30 days after last dose or during 25 months)
- relapse at 5 years (cohorts C and D)(After 5 years since last patient treatment initiation)
- Tumor cells response to the treatment(Week 11, at surgery)
- Questionnaire(every 3 months during 24 months)