ACTRN12614001294640招募中未知
Study of intermediate risk subjects with a family history of coronary artery disease to identify whether management based on coronary calcium scoring vs usual care leads to reduction of coronary plaque volume progression and adverse cardiovascular events
Baker-IDI Heart and Diabetes Institute0 个研究点目标入组 734 人开始时间: 2014年12月11日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 发起方
- 入组人数
- 734
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Prevention
- 盲法
- Open (masking not used)
入排标准
- 年龄范围
- 40 Years 至 70 Years（—）
- 性别
- All
入选标准
- •Asymptomatic subjects age 40-70y
- •- Family history of CAD involving an index patient <60y (1st degree) or <50y (2nd degree)
- •- Not already on statins
- •- Total cholesterol < 6.5 mmol/L and LDL cholestrerol <5 mmol/L
- •- CAD 5-year risk (Australian risk calculator) 2.5-15%
排除标准
- •- Symptomatic coronary, cerebrovascular, or peripheral vascular disease
- •- Intolerance of statins or already on statins
- •- Pre-existing muscle disease (eg polymyositis, fibromyalgia)
- •- Atrial fibrillation
- •- Chronic kidney disease on haemodialysis
- •- Inability to provide informed consent
- •- Major systemic illness eg malignancy, rheumatoid arthritis
- •- Women of child bearing potential
- •- Poorly controlled hypertension: SBP> 200 and or DBP > 100
- •- Severe psychiatric disorder (eg bipolar depression; psychosis)
研究者
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