Effect of magnesium sulphate on total amount of muscle relaxant required to conduct deep and moderate neuromuscular block surgeries and the effect of magnesium sulphate on total amount of fentanyl required to releive postoperative pain after these surgeries.
Phase 4
Not yet recruiting
- Conditions
- Calculus of gallbladder with acutecholecystitis, (2) ICD-10 Condition: O||Medical and Surgical,
- Registration Number
- CTRI/2021/02/031434
- Lead Sponsor
- ANUREET KAUR
- Brief Summary
A total of 80 patients will be divided into 4 groups A, B, C and D. Magnesium pretreatment will be given in groups A and C i.e. Deep neuromuscular blockade group with magnesium and Moderate neuromuscular blockade witj magnesium . Control groups are group B and group D i.e. Deep neuromuscular blockade with control and Moderate neuromuscular block with control. Deep neuromuscular block will be given in groups A and B and moderate block will be given in groups C and D.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
1)ASA grade 1,2,3 2)Patients aged between 18 to 60 years 3)BMI <35 Kg/m2 4)Patients scheduled for laproscopic cholecystectomy under General Anaesthesia.
Exclusion Criteria
- 1)Patient refusal to give consent 2)Patients with known hypersensitivity to magnesium and cis Atracurium 3)Pregnant patients 4)Patients with history of abdominal surgery 5)Patients with major organ dysfunction 6)Patients using any hypnotics or analgesic 7)Patients having neuromuscular disease that may interfere with neuromuscular function 8)Patients receiving medications known to influence neuromuscular function(eg.
- calcium channel blockers, phenytoin and aminoglycosides).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To calculate and compare total cisatracurium consumption in deep and moderate neuromuscular blockade groups with and without magnesium sulphate After intubation of patient, at 5 minutes , 10 minutes , 15 minutes , 20 minutes , 25 minutes, 30 minutes , 35 minutes , 40 minutes , 2 hours, 6 hours, 12 hours.
- Secondary Outcome Measures
Name Time Method To calculate Minimum effective analgesic dose of fentanyl in post anaesthesi care unit, mean VAS score at rest, on movement and on wound compression 2 hr, 6 hr, 12 hr after surgery
Trial Locations
- Locations (1)
GGS MEDICAL COLLEGE AND HOSPITAL, FARIDKOT, PUNJAB
🇮🇳Faridkot, PUNJAB, India
GGS MEDICAL COLLEGE AND HOSPITAL, FARIDKOT, PUNJAB🇮🇳Faridkot, PUNJAB, IndiaAnureet KaurPrincipal investigator9478358947bajwaanureet74.akb@gmail.com