The Relationship Between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients

Completed

• Conditions: Cohort Studies

• Registration Number: NCT06861764
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

This study is a retrospective analysis of a large-scale multicentre prospective cohort study that investigates the the relationship between Preoperative Anxiety and Postoperative Delirium in Elderly Chinese Patients: a Multicenter Prospective Cohort

Detailed Description

This is a retrospective cohort study using prospective data from a multicenter database. 8000 elderly patients undergoing elective non-cardiac or non-neurosurgical surgery were included in this study. The Generalized Anxiety Disorder Scale (GAD-7) was used to measure preoperative anxiety symptoms. The confusion assessment method (3D-CAM) was used to assess postoperative delirium in elderly patients undergoing non-cardiac surgery. If the patient is discharged, follow up by phone or email. Binary logistic regression analysis and propensity score matching (PSM) and subgroup analysis were used to analyze the data.

Study Timeline

• Study Start: 2020-04-01
• Primary Completion: 2022-04-30
• Study Completion: 2022-04-30
• Status Verified: 2025-02
• Study First Submitted: 2025-03-01
• Study First Submitted QC: 2025-03-01
• Study First Posted: 2025-03-06
• Last Update Submitted: 2025-03-18
• Last Update Posted: 2025-03-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 8000

Inclusion Criteria

• elderly patients (age ≥ 65 years)
• non-cardiac surgery, non-neurosurgical surgery

Exclusion Criteria

• History of neurological or psychiatric disorders or use of neuropsychiatric drugs;
• Impaired cognitive function or inability to cooperate with preoperative follow-up;
• Sent to ICU after surgery;
• Deletional delirium outcome;
• Baseline missing >5%

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Postoperative delirium	within 7 days after surgery	The incidence of postoperative delirium was assessed by a 3-minute diagnostic interview in the surgical ward (3D-CAM).

Trial Locations

Locations (1)

Chinese PLA General Hospital; 🇨🇳 Beijing, Beijing, China