Quantification of Autonomic Nervous Activity During Hemodialysis
- Conditions
- Chronic Kidney Disease on Hemodialysis
- Registration Number
- NCT02754986
- Lead Sponsor
- University of Hyogo
- Brief Summary
This study assesses autonomic nervous system function by power spectral analysis of RR interval dynamics in ultrafiltration subjects without blood pressure variation.
- Detailed Description
Variations over time in autonomic nervous activity due to differences in ultrafiltration rate will be evaluated by measuring heart rate variability in hemodialysis patients without blood pressure variations during HD session.
The subjects will be divided into 3 groups, those with UFR \< 10 ml/hr/kg; ≥10 ml/hr/kg but ≤ 15 ml/hr/kg; and \>15 ml/hr/kg, and Holter ECG are recorded continuously during HD session using frequency analysis of RR intervals.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 35
- Patients with stable undergoing hemodialysis without hanging in blood pressure during hemodialysis.
- Patients with chronic atrial fibrillation
- Patients with frequent ventricular premature beats
- Patients with a permanent pacemaker
- Patients with taking antihypertensive drugs
- Patients with medical treatment due to changes in blood pressure
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method The outcome measures was low frequency power (LF, ms2) to high frequency power (HF, ms2) ratio (LF/HF ratio) of heart rate variability. The three subject groups with difference ultrafiltration were compared by LF/HF ratio during hemodialysis session. 4 hours Variations over time in autonomic nervous activity due to differences in ultrafiltration rate will be evaluated by measuring heart rate variability.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Graduate School of Applied Informatics, University of Hyogo
🇯🇵Kobe, Hyogo, Japan
Graduate School of Applied Informatics, University of Hyogo🇯🇵Kobe, Hyogo, Japan