Quantification of Autonomic Nervous Activity During Hemodialysis

Not Applicable

Completed

• Conditions: Chronic Kidney Disease on Hemodialysis
• Interventions: Other: Analysis of the holter electrocardiogram

• Registration Number: NCT02754986
• Lead Sponsor: University of Hyogo

Brief Summary

This study assesses autonomic nervous system function by power spectral analysis of RR interval dynamics in ultrafiltration subjects without blood pressure variation.

Detailed Description

Variations over time in autonomic nervous activity due to differences in ultrafiltration rate will be evaluated by measuring heart rate variability in hemodialysis patients without blood pressure variations during HD session.

The subjects will be divided into 3 groups, those with UFR \< 10 ml/hr/kg; ≥10 ml/hr/kg but ≤ 15 ml/hr/kg; and \>15 ml/hr/kg, and Holter ECG are recorded continuously during HD session using frequency analysis of RR intervals.

Study Timeline

• Study Start: 2015-03
• Primary Completion: 2015-08
• Status Verified: 2016-03
• Study First Submitted: 2016-03-01
• Study First Submitted QC: 2016-04-25
• Last Update Submitted: 2016-04-25
• Study First Posted: 2016-04-28
• Last Update Posted: 2016-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Patients with stable undergoing hemodialysis without hanging in blood pressure during hemodialysis.

Exclusion Criteria

• Patients with chronic atrial fibrillation
• Patients with frequent ventricular premature beats
• Patients with a permanent pacemaker
• Patients with taking antihypertensive drugs
• Patients with medical treatment due to changes in blood pressure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
measuring Holter electrocardiogram	Analysis of the holter electrocardiogram	Hotter ECG will be recorded continuously during hemodialysis

Primary Outcome Measures

Name	Time	Method
The outcome measures was low frequency power (LF, ms2) to high frequency power (HF, ms2) ratio (LF/HF ratio) of heart rate variability. The three subject groups with difference ultrafiltration were compared by LF/HF ratio during hemodialysis session.	4 hours	Variations over time in autonomic nervous activity due to differences in ultrafiltration rate will be evaluated by measuring heart rate variability.

Trial Locations

Locations (1)

Graduate School of Applied Informatics, University of Hyogo; 🇯🇵 Kobe, Hyogo, Japan