Enthesis Differences in Rheumatoid Arthritis and Axial Spondyloarthropathy

Completed

• Conditions: Enthesitis; Rheumatoid Arthritis; Enthesopathy; Axial Spondyloarthritis
• Interventions: Other: ULTRASOUND

• Registration Number: NCT05942976
• Lead Sponsor: Istanbul Training and Research Hospital

Brief Summary

The aim of this study is to investigate the sonographic differences in entheses in patients with Rheumatoid arthritis and Axial Spondyloarthropathy.

Detailed Description

After recording the demographic data of the patients; 5 enthesis regions 5 enthesis sites were evaluated bilaterally as ''tricipital tendon (TT), quadricipital tendon (QT), proximal patellar tendon (PPT), distal patellar tendon (DPT), achilles tendon (AT)'' will be sonographically evaluated and the presence of hypoechogenicity , tendon thickness increase, power Doppler activity, erosion, presence of entezophyte/calcification will be investigated. The differences between the groups will then be compared.

Study Timeline

• Study Start: 2023-06-16
• Study First Submitted: 2023-06-27
• Study First Submitted QC: 2023-07-11
• Study First Posted: 2023-07-12
• Primary Completion: 2023-07-15
• Study Completion: 2023-08-15
• Status Verified: 2023-09
• Last Update Submitted: 2023-09-03
• Last Update Posted: 2023-09-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

• Rheumatoid arthritis patients identified according to the 2010 American College of Rheumatology /Europan Leage Against Rheumatism classification criteria,
• axial Spondyloarthrtis patients identified according to the Assessment of Spondyloarthritis classification criteria
• healthy controls with no history of rheumatic diseases.

Exclusion Criteria

• history of limb trauma and surgery in the last 3 months,
• metabolic disease (diabetes mellitus, hypothyroidism),
• malignant neoplasm,
• limitation of range of motion in the extremity,
• those who have received corticosteroid injections in the last 3 months,
• uncontrollable fibromyalgia.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
group 2: Rheumatoid arthritis	ULTRASOUND	RA patients identified according to the 2010 American College of Rheumatology/Europan Leage Against Rheumatism classification criteria
group 1: axial spondyloarthritis	ULTRASOUND	SpA patients identified according to the Assessment of Spondyloarthritis classification criteria
group:3 Healthy Control	ULTRASOUND	healthy controls with no history of rheumatic diseases

Primary Outcome Measures

Name	Time	Method
The relationship between ultrasound findings and disease parameters	2 months	The relationship between triceps tendon, quadriceps tendon, proximal patellar tendon, distal patellar tendon and achilles tendons enthesitis scores and Clinical disease activity index and BASDAI
Ultrasound enthesis differences between the groups	2 months	triceps tendon, quadriceps tendon, proximal patellar tendon, distal patellar tendon and achilles tendons enthesitis scores differences between the groups

Trial Locations

Locations (1)

Istanbul Training and Resarch Hospital; 🇹🇷 Istanbul, Turkey