Investigating the Noradrenergic System in the Living Human Brain With Hybrid Molecular Functional Imaging
试验速览
- 阶段
- 不适用
- 入组人数
- 135
- 试验地点
- 1
- 主要终点
- Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) measures
研究概览
简要总结
The main goal of this research proposal is to provide, for the first time in humans, a wider understanding of the role of the noradrenergic system both in health and illness (Parkinson's disease) through the use of a newly developed radiotracer (11Carbon [11C]Yohimbine) visualizing alpha-2 (α2) adrenergic receptors (AR) combined with cutting-edge technology, the hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI) scanner. The secondary aim of this study will be to determine whether the expected age- and Parkinson's disease (PD)-related changes in the noradrenergic system are paralleled by changes in neuropsychological performances (such as cognitive, motor and/or olfactory abilities).
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Subject with alcohol or substance abuse history
- •Subject with somatic drug therapies
- •Magnetic Resonance Imaging (MRI) contraindications (implanted or embedded metal objects in the head or body)
- •Positron Emission Tomography (PET) contraindications
- •Exposed to 1 millisievert or more of ionizing radiation in the year before the start of this study
- •Subject unable to sign written consent for participation in the study
研究组 & 干预措施
Healthy controls
干预措施: The role of the noradrenergic system across the life span (Healthy Subjects) (Other)
Parkinson disease
干预措施: The role of the noradrenergic system across the life span (Parkinson's Disease Subjects) (Other)
结局指标
主要结局
Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) measures
时间窗: Day 1 -180 minutes
Derived from the Positron Emission Tomography (PET) data, the binding potentials will be calculated using compartmental modelling techniques. Derived from the Magnetic Resonance Imaging (MRI) data.
次要结局
- Global Cognitive Assessment(Day 2 - 10 minutes)
- Memory Assessment(Day 2 - 20 minutes)
- Working Memory Assessment(Day 2 - 20 minutes)
- Olfactory assessment : odor detection(Day 2 - 30 minutes)
- Planning Functioning(Day 2 - 20 minutes)
- Visuo-spatial Assessment(Day 2 - 20 minutes)
- Anxiety Evaluation(Day 2 - 10 minutes)
- Olfactory assessment : odor identification(Day 2 - 30 minutes)
- Depression Evaluation(Day 2 - 10 minutes)
- Olfactory assessment: odor discrimination(Day 2 - 30 minutes)
- Executive Functioning(Day 2 - 20 minutes)
- Praxic Abilities(Day 2 - 10 minutes)
- Day time sleepiness evaluation(Day 2 - 5 minutes)
- Sleep Quality(Day 2 - 5 minutes)