Effect of endoscopic treatments of Barrett's oesophagus on oesophageal motility and reflux
Completed
- Conditions
- oesophageal motilityreflux10017943
- Registration Number
- NL-OMON30256
- Lead Sponsor
- St. Antonius Ziekenhuis
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Barrett's oesophagus with high-grade dysplasia
Scheduled for endoscopic treatment with SRER or BARRx
Exclusion Criteria
Prior surgery of the stomach or oesophagus
condition with contraindicates the cessation of PPI therapy such as peptic ulcer disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Using oesophageal manometry the following parameters will be assessed: % of<br /><br>contractions that are peristaltic, contraction amplitude and duration in the<br /><br>proximal and distal oesophagus, lower oesophageal sphincter pressure and<br /><br>relaxation nadir pressure. Impedance-pH measurements will be analyzed for<br /><br>number and type (acid, weakly acidic, liquid, gas or mixed liquid-gas reflux)<br /><br>of reflux episodes and proximal extent of the reflux episodes. In addition, %<br /><br>of time with oesophageal pH<4.0 will be determined. </p><br>
- Secondary Outcome Measures
Name Time Method <p>-</p><br>