Randomized, Single-Blind Study to Evaluate the Pharmacokinetics, Biomarkers, Safety and Tolerability of STAT-205 in Adult Patients With Mild COVID 19 Who Are at High Risk of Disease Progression
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Proportion of patients who demonstrate progression of COVID-19 disease
研究概览
简要总结
This is a randomized, single blind, study. Males and females meeting inclusion criteria who have symptoms of mild COVID-19 and in whom a positive PCR result for SARS-CoV-2 is obtained may be enrolled to the study treatment within 72 hours of the positive PCR result. Eligible patients are those considered to be at high risk for COVID-19 disease progression. This includes patients ≥ 65 years of age or with any one or more of certain medical conditions including: cancer, COPD, cardiovascular disease, immunocompromised state resulting from solid organ transplant, obesity, sickle cell disease, history of smoking, and diabetes.
详细描述
Eligible patients will be randomized, 1:2, to either placebo or STAT-205. Randomization will be stratified by site. STAT-205 treatment will include an initial 5-day dosing period (period 1) of 22.5 mg QD, to be followed by a second dosing period (period 2) of 4.5 mg QD to complete 30 days of dosing. Patients randomized to placebo will receive placebo QD. Blood samples for pharmacokinetic analysis and measurement of inflammatory biomarkers will be collected from patients on day 1, day 6, day 15 and day 30. Patients will be seen in the clinic on days 1, 6, 15, and 30. Patients will be contacted via telephone for follow up on day 60 and on. each post treatment day through Day 60. The telephone visit should occur at approximately the same time each day. During the telephone visits, the presence and severity of COVID-19 symptoms that were recorded at Baseline will be queried, and any new symptoms will be recorded. During the daily telephone visits, patients will also be queried for any adverse events.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
盲法说明
double-blind
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >18 at the time of informed consent
- •Able to understand and provide informed consent in either English or Spanish
- •At high risk for COVID-19 disease progression by fulfilling at least ONE of the following criteria at Screening:
- •Age ≥65 years
- •Has a diagnosis of chronic pulmonary disease requiring daily treatment (e.g. COPD, chronic persistent asthma, cystic fibrosis, chronic bronchitis)
- •Has a diagnosis of chronic heart disease
- •Has a diagnosis of diabetes (type 1 or type 2) requiring oral therapy and/or insulin therapy
- •Has hypertension requiring at least one oral medication for treatment
- •Has a body mass index (BMI) of ≥33 kg/m2
- •Has an immunocompromising disease (e.g. HIV infection with CD4 count < 200 cells/mm3)
- •Is immunocompromised due to daily treatment with ≥20 mg of prednisone or equivalent
- •Has received a solid organ transplant
- •Has any chronic condition that, in the opinion of the investigator, places the patient at increased risk for progression of COVID-19
- •Documentation of positive diagnostic test for SARS-CoV-2 (confirmed by PCR assay or other approved diagnostic test) performed with a sample from nares or saliva, collected within 7 days of the Screening visit.
- •Is symptomatic for COVID-19 for no more than 7 days prior to the Screening visit
- •Has a WHO Clinical Progression Scale (WHOb 2020) score of either '2' or '3' at Screening and Randomization
- •Has at least one of the following symptoms at the Screening visit that are new in onset, or if present by history, has worsened during the 7 days prior to Screening:
- •· fever, chills, myalgia, arthralgia, headache, fatigue, cough, sore throat, nasal congestion, nausea, vomiting, diarrhea, anosmia or dysosmia, ageusia or dysgeusia
- •If female of child-bearing potential, must agree to use of 2 forms of contraception from Screening to end of the study. Males must agree to use 2 forms of contraception from screening to the end of the study if their partners are of childbearing potential. Acceptable methods of birth control which must be used together are:
- •Oral or injectable contraceptive and condom, or
- •IUD and condom, or
- •Diaphragm with spermicide and condom.
- •Agrees to participate in all in-person visits and remote or home visits as required by the protocol and to provide updated contact information, as necessary.
排除标准
- •Has a WHO Clinical Progression Scale (WHOb 2020) score of '4' or higher at Screening or Enrollment
- •Previous hypersensitivity or allergic reactions to naltrexone
- •Women who are pregnant or lactating or expecting to become pregnant
- •Drugs of abuse screen positive for opiates
- •Patients with history of moderate to severe renal impairment (estimated creatinine clearance < 50 mL/min) or hepatic impairment (Child-Pugh C)
- •Serum ALT or AST value > 3 times the ULN at Screening
- •Serum creatinine value > 2 times the ULN at Screening, or requires renal dialysis
- •Hematology results at Screening showing any one of the following: WBC <2000 cells/mm3 or platelet count <100,000 cells/mm3 or hemoglobin <8.5 Gm/dL
- •Currently receiving chronic daily opioid therapy
- •Use of tocilizumab or other immunomodulator therapy directed to treatment or prevention of COVID-19
- •History of active substance abuse within the 2 years prior to Screening
- •Participation in another clinical trial investigating a treatment for COVID-19
- •Currently hospitalized or under immediate consideration for hospitalization (for any medical reason) at the Screening visit
- •At Screening, has new onset of dyspnea (shortness of breath) or, if previously diagnosed with a chronic lung condition, the severity of dyspnea has increased over patient's historical baseline condition (increased dyspnea should be present continually and not intermittent)
- •Measurement of oxygen saturation at Screening is < 94% on ambient room air
- •Shares a household with a patient currently enrolled in this protocol
- •Patients who refuse biomarker blood draws
研究组 & 干预措施
Placebo
Dosing Period 1: Placebo (five capsules) Dosing Period 2: Placebo (one capsule)
干预措施: STAT-205 (Drug)
STAT-205
Dosing Period 1: 22.5 mg STAT-205 (five 4.5 mg capsules) Dosing Period 2: 4.5 mg STAT-205 (one capsule)
干预措施: STAT-205 (Drug)
结局指标
主要结局
Proportion of patients who demonstrate progression of COVID-19 disease
时间窗: Day 1 to Day 30
Progression of COVID-19 disease based on the WHO clinical progression scale (WHOb2020)
次要结局
未报告次要终点