Superadded Value of Functional MRI Techniques in Evaluation of Malignant Breast Cancers Following Clips Guided Neoadjuvant Chemotherapeutic Series
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- changes in the different functional technique's parameters according to the type of response.
研究概览
简要总结
• Address the accuracy of functional MRI techniques to predict response to neoadjuvant chemotherapy given to local advanced breast cancer patients with correlation with pathology thus allowing early chemotherapy regimen modification to increase number of patients achieving pathological complete response or save patients from toxic effects of ineffective chemotherapy.
详细描述
patient selection:
Selection of patients diagnosed with of biopsy proven breast cancer (BIRAD VI ) :
• Inclusion criteria: patient in different age groups with local advanced breast cancer who are eligible for neoadjuvant chemotherapy and breast conservative surgery and in need for clip placement for tumor localization
Breast cancer (BC) is the second most common cancer in the world and by far the most frequent cancer among women. In Egypt the incidence rate of breast cancer is 29.9/100,000 population in the age group of 30-34 years with the highest population among young women. (1).
Management of breast cancer depends upon its stage. Early stages (stage I) with small sized breast masses undergo breast conservative surgery (BCS) while locally advanced breast masses (stage II and III) may require Preoperative administration of Neoadjuvant chemotherapy (NAC) to decrease the tumor burden allowing for BCS instead of mastectomy with no significant difference in disease-free survival for patients receiving breast conservation in comparison to mastectomy.(2, 3)
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient in different age groups with local advanced breast cancer who are eligible for neoadjuvant chemotherapy and breast conservative surgery and in need for clip placement for tumor localization
排除标准
- •Patient with breast cancer who are not eligible for NAC (pregnant patients, multicentric breast cancer, metastatic breast cancer).
- •Patients who have received any prior chemotherapy, radiation therapy or tamoxifen therapy for their current breast cancer
- •Patients with any general contraindication to MRI as presence of any paramagnetic substance as pacemakers, or those with claustrophobia.
结局指标
主要结局
changes in the different functional technique's parameters according to the type of response.
时间窗: 3 years
by appropriate statistical test
correlations coefficient between functional techniques of MRI breast and histology
时间窗: 3 years
by appropriate statistical test
次要结局
未报告次要终点
研究者
Heba Sabet
Assistant lecturer of Radiology
Assiut University