Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- The primary aim is to determine the role of superficial and deep cortical layers of M1 in the consolidation of motor skill learning.
研究概览
简要总结
Background:
Training in a new motor skill often involves periods of active practice and periods of rest. During early motor skill learning, improvements in performance usually happen during the short rest periods between practice sessions. Researchers want to use improved imaging techniques to study the contributions of specific parts of the brain to how people learn and retain movement skills.
Objective:
To learn the part played by different layers in the brain in retaining a newly learned movement skill.
Eligibility:
Healthy, right-handed, English-speaking people age 18-50.
Design:
Participants will be screened with:
- Medical and neurological history
- Medicine review
- Physical exam
- Neurological exam.
Participants may have 2 magnetic resonance imaging (MRI) scans of the brain. During the MRI, they will lie in the scanner. The scanner makes noise. They will get earplugs.
Participants will have behavior testing. A specific order of keys will be displayed on a computer screen. Participants will practice typing the keys with their left hand 36 times (in 10-second blocks). They will repeat this test with a random order of keys.
Participants will see single numbers displayed one after the other on the computer screen. They will make single tap responses using the finger that corresponds with the number on the screen.
Participants will have up to 4 study sessions. Each session will take about 5 hours.
详细描述
Study Description:
Training on a novel motor skill often involves periods of active practice interspersed with periods of rest. During early motor skill learning, performance improvements develop primarily during short offline rest periods that occur between practice blocks. These performance gains during rest have been referred to as 'micro-offline consolidation'. Primary motor cortex (M1) is a crucial contributor to skill consolidation, however, due to the poor spatial specificity and vascular biases of available imaging methods, the specific neural mechanisms of consolidation in M1 are not known. Recent innovations in functional magnetic resonance imaging (fMRI) have made it possible to measure functional changes across cortical layers. This study will use these techniques to investigate the contributions of specific cortical layers in M1 to motor skill learning and consolidation.
Objectives:
The primary aim is to determine the correlation between activity in superficial M1 cortical layers and behavioral gains during microoffline rest periods. Additionally, we will evaluate the role of superficial and deep cortical layers of M1 in the consolidation of motor skill learning. To address this question, we will measure neural activations across cortical laminae in M1 while participants consolidate a newly acquired motor skill.
Endpoints:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •INCLUSION CRITERIA:
- •Age 18-50
- •English speaking
- •Right-hand dominance (>74 on Edinburgh Handedness Inventory)
- •Normal neurological examination
- •Willing and able to provide informed consent
排除标准
- •HCPS-affiliated NIH staff (i.e. - staff from our section).
- •Current pregnancy
- •Current or past history of use of antiepileptic drugs
- •Contraindications for MRI (such as certain implants, metal fragments or devices in the body) as determined by the screening clinician
- •Severe or progressive neurological, psychological or medical condition
研究组 & 干预措施
Participants
Healthy right-handed participants aged 18-50
结局指标
主要结局
The primary aim is to determine the role of superficial and deep cortical layers of M1 in the consolidation of motor skill learning.
时间窗: 4 years
To address this question, we will measure neural activations across cortical laminae in M1 while participants consolidate a newly acquired motor skill.
次要结局
未报告次要终点