A Comparative Study of Neoral in combination with Corticosteroid comparing to Corticosteroid alone in patients with Nephrotic syndrome
- Conditions
- ephrotic syndrome
- Registration Number
- JPRN-UMIN000003245
- Lead Sponsor
- Kyoto university hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Not provided
Exclusion Criteria Patients who meet following criteria will be excluded from this study. 1. Patients with renal impairment that is defined as that creatinin clearance is less than 50ml/min calculated from serum creatinin and from pooled urine creatinin. 2. Patients who are diagnosed as a steroid resistant nephrotic syndrome. 3. Patients who have to take any drugs, which have renal toxicity. 4. Patients with malignancy or history of malignancy. 5. Patients who have uncontrollable hypertension by any treatment. 6. Patients with malabsorption syndrome, cerebral circulatory disturbance or seizure 7. Patients with cardiac, liver or pancreatic severe disease 8. Patients who are pregnancy, lactation or suspicion of pregnancy. 9. Patients who are considered that immunosuppressive drugs should not be used due to infection. 10. Patients who have an episode of allergic reaction to any ingredients of Neoral. 11. Patients who are judged ineligible to enroll into this trial due to any reasons by the study physician.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method rine protein (mg/day)
- Secondary Outcome Measures
Name Time Method Remission Frequency of Recurrence Duration of hospitalization Cumulative dose of corticosteroid Creatinine Clearance Serum Creatinine Serum albumin Total protein (serum) Total cholesterol (serum) Edema