Real-time fMRI Neurofeedback as a Treatment Tool for Alcohol Dependence - Protocol Optimisation Phase
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Cardiff University
- Enrollment
- 15
- Locations
- 1
- Primary Endpoint
- Neurofeedback success (brain activation difference during neurofeedback and baseline blocks)
Study Overview
Brief Summary
Participants will undergo a single session of functional magnetic resonance imaging (fMRI)-based neurofeedback (approximately 1 hour). The investigators will assess their ability to regulate motivational networks of the brain during the exposure to alcohol cues and evaluate immediate effects on craving and cognitive bias for alcohol by administering a questionnaire and a Stroop task before and after the session.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •History of alcohol use disorder or current alcohol consumption above 21 units (1 unit = 8g) of alcohol per week (male participants) or above 14 units of alcohol per week (female participants)
Exclusion Criteria
- •MRI safety exclusion criteria
Arms & Interventions
Neurofeedback
Intervention: Neurofeedback (Other)
Outcomes
Primary Outcomes
Neurofeedback success (brain activation difference during neurofeedback and baseline blocks)
Time Frame: 1 day
This measure will be based on the analysis of participants' fMRI (functional magnetic resonance imaging) data, reflecting brain activation, during exposure to alcohol cues. Neurofeedback success will be defined as significant difference between activation levels (expressed as beta weights of a linear regression model) during the regulation periods compared to baseline. The significance will be determined by a t-test.
Secondary Outcomes
- Alcohol Stroop task as a measure of cognitive bias(1 day)
- Drinking Urges Questionnaire as a measure of alcohol craving(1 day)
Investigators
David Linden
Professor of Translational Neuroscience
Cardiff University