Optimisation of Functional MRI-based Neurofeedback for Alcohol Use Disorders

Not Applicable

Completed

• Conditions: Alcohol Abuse
• Interventions: Other: Neurofeedback

• Registration Number: NCT02406456
• Lead Sponsor: Cardiff University

Brief Summary

Participants will undergo a single session of functional magnetic resonance imaging (fMRI)-based neurofeedback (approximately 1 hour). The investigators will assess their ability to regulate motivational networks of the brain during the exposure to alcohol cues and evaluate immediate effects on craving and cognitive bias for alcohol by administering a questionnaire and a Stroop task before and after the session.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-03
• Study First Submitted: 2015-03-26
• Study First Submitted QC: 2015-03-30
• Study First Posted: 2015-04-02
• Primary Completion: 2015-08
• Study Completion: 2015-08
• Status Verified: 2015-11
• Last Update Submitted: 2015-11-10
• Last Update Posted: 2015-11-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• History of alcohol use disorder or current alcohol consumption above 21 units (1 unit = 8g) of alcohol per week (male participants) or above 14 units of alcohol per week (female participants)

Exclusion Criteria

• MRI safety exclusion criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Neurofeedback	Neurofeedback	-

Primary Outcome Measures

Name	Time	Method
Neurofeedback success (brain activation difference during neurofeedback and baseline blocks)	1 day	This measure will be based on the analysis of participants' fMRI (functional magnetic resonance imaging) data, reflecting brain activation, during exposure to alcohol cues. Neurofeedback success will be defined as significant difference between activation levels (expressed as beta weights of a linear regression model) during the regulation periods compared to baseline. The significance will be determined by a t-test.

Secondary Outcome Measures

Name	Time	Method
Alcohol Stroop task as a measure of cognitive bias	1 day	Measure of cognitive bias
Drinking Urges Questionnaire as a measure of alcohol craving	1 day	Measure of alcohol craving

Trial Locations

Locations (1)

School of Medicine, Cardiff University; 🇬🇧 Cardiff, Wales, United Kingdom