Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- headache and associated symptoms
研究概览
简要总结
The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to Calcitonin Gene Related Peptide (CGRP)infusion.
详细描述
Calcitonin Gene Related Peptide (CGRP) induces migraine attacks indistinguishable from spontaneous attacks in approximately 50% of migraine sufferers. Treatment of spontaneous migraine attacks with an antagonist to CGRP is effective in many patients. These data show that CGRP is involved in both initiation and maintenance of migraine attack.
The consequence of migraine gene mutations on relevant migraine pathways has never been tested. The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to CGRP infusion. The project will improve our understanding of the neurobiology of migraine and stimulate development of new treatment targets.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Educational Counseling Training
- 盲法
- Single
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients: Diagnosis of familial hemiplegic migraine (IHS-classification criteria) caused by mutations in the CACNA1A gene and the ATP1A2 gene.
- •Controls: Healthy volunteers
排除标准
- •Controls: No primary headache in their own history 2) Patients and controls:
- •A history of cerebrovascular disease and other CNS- disease
- •A history of serious somatic and mental disease
- •A history suggesting ischaemic heart disease
- •A history of hypo- or hypertension
- •Daily intake of medication apart from oral contraceptives
- •Abuse of alcohol or medicine (opioid analgesics).
- •Pregnant or breastfeeding women.
- •On the study day:
- •No intake of a simple analgesic in the previous 48 hours
- •No headache in the previous 48 hours
结局指标
主要结局
headache and associated symptoms
blood flow velocity of the middle cerebral artery
diameter of the superficial temporal artery
次要结局
- MAP
- HR