Breath Analysis for SARS-CoV-2 in Infected and Healthy Subjects
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- SARS-CoV-2 Infection
- Sponsor
- Klinikum Bayreuth GmbH
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- correct classification of SARS-CoV-2 infected and not infected subjects
- Last Updated
- 5 years ago
Overview
Brief Summary
Recently published studies could demonstrate that detection of specific biomarkers in breath could be applied for the diagnosis of SARS-CoV-2.
Detailed Description
In this study we want to address the sensitivity and specificity of breath analysis by MCC-IMS in the context of SARS-CoV-2 detection from PCR- proven infected and non-infected subjects. Therefore nasal breath will be aspirated for 10 seconds during normal respiration by a foam cuffed oxygen catheter connected via a 0.22μm filter and a line into the MCC-IMS and directly analyzed without any pre-analytic procedures. The during the proof-of-concept study derived significant peaks for volatile organic compounds will be used for discrimination in a point-of-care approach.
Investigators
Eligibility Criteria
Inclusion Criteria
- •hospital admission staff members
Exclusion Criteria
- •too sick to comply with study procedures
Outcomes
Primary Outcomes
correct classification of SARS-CoV-2 infected and not infected subjects
Time Frame: 6 months
correct classification of SARS-CoV-2 infected and not infected subjects