Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic in Patients Undergoing Orthopedic Surgeries Under Spinal Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 142
- 试验地点
- 1
- 主要终点
- Pain severity
研究概览
简要总结
There are extensive gaps in the local data considering pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia. Therefore, the current study was planned with the objective of comparing pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia.
详细描述
Since postoperative pain in orthopedic surgery, whether neuropathic or nociceptive, presents a significant challenge for both surgeons and patients, knowing the more effective gabapentinoid as a pre-emptive analgesic would help clinicians to offer prolonged timing of first rescue analgesia and less opioid consumption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Either gender
- •Aged 20-60 years
- •Undergoing lower limb orthopedic surgeries under spinal anesthesia
排除标准
- •Patients with a previous history of spine interventions, including surgery or injections (transforaminal, epidural, or facetal) for pain relief
- •Patients under any sort of pain modulation therapy, like transcutaneous electrical nerve stimulation
- •Patients had a long-term history of any analgesia use
- •Those with psychiatric disorders, alcohol/drug dependence, hepatic, renal, cardiac, or pulmonary abnormalities,
- •With a history of allergies to gabapentinoids
研究组 & 干预措施
Group-G
Patients were given a single oral dose of gabapentin 300 mg, with 30 ml of water, one hour prior to administration of spinal anesthesia.
干预措施: Gabapentin (Drug)
Group-P
Patients received pregabalin 150 mg as a single oral dose, with 30 ml of water, one hour prior to administration of spinal anesthesia
干预措施: Pregabalin (Drug)
结局指标
主要结局
Pain severity
时间窗: 24 hours
The severity of pain was analyzed on the visual analogue scale (VAS), with a lower score labelling the effectiveness of the treatment.
Analgesia duration
时间窗: 24 hours
The duration of analgesia was measured from awakening to the need of rescue analgesia, when a pain score was more than 3 on VAS.
次要结局
未报告次要终点
研究者
Muhammad Aamir Latif
Research Consultant
RESnTEC, Institute of Research