Evaluation of cytology and HPV testing for testing for anal intraepithelial neoplasia in high-risk populations in the UK
Not Applicable
Completed
- Conditions
- CancerTopic: Infection, Generic Health Relevance and Cross Cutting ThemesSubtopic: Infection (all Subtopics), Generic Health Relevance (all Subtopics)Disease: Infectious diseases and microbiology , SurgeryMalignant neoplasm of anus and anal canal
- Registration Number
- ISRCTN69055668
- Lead Sponsor
- Central Manchester University Hospitals NHS Trust (CMFT) (UK)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 1000
Inclusion Criteria
1. HIV positive men and women who have anal intercourse attending NHS genitourinary medicine (GUM) clinics
2. Men who have sex with men (MSM), recruited through GUM clinics and specialist general practices
3. Immunosuppressed transplant recipients (men and women) attending transplant follow-up clinics
Exclusion Criteria
Patients with prior history of anal neoplasia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluation of LBC and HPV testing/typing and anoscopy as potential screening tests at end of study
- Secondary Outcome Measures
Name Time Method 1. Feasibility of recruitment, screening and follow up<br>2. Patient acceptability of screening for anal neoplasia <br>3. Reliable estimates of prevalence of anal cytological abnormality and HPV positivity by type<br><br>Measured at end of study