NCT00771082终止不适用
Osteoarthritis and Body Composition: Evaluation of Systematic Mediators
National Institute on Aging (NIA)1 个研究点 分布在 1 个国家目标入组 1,033 人开始时间: 2003年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 1,033
- 试验地点
- 1
- 主要终点
- Changes in inflammatory marker c-reactive protein
研究概览
简要总结
The purpose of this study is to examine the relationship between body composition and knee osteoarthritis, and effects of inflammatory, metabolic, and hormonal factors.
详细描述
Banked serum and urine specimens obtained from NIA Baltimore Longitudinal Study on Aging (BLSA) participants with and without knee OA will be used to determine inflammatory, metabolic, bone and joint biomarkers in an observational, case-control study. This study will be limited to BLSA data and samples that have already been acquired and stored.
The specific aims of this study are to:
- Examine the association between prevalent radiographic osteoarthritis (OA), concurrently obtained inflammatory and metabolic mediator levels and change in bone density and bone markers over time subsequent to radiographic classification.
- Determine levels of inflammatory, metabolic and bone markers, and body composition when radiographic OA was absent, and examine their relationship to the development of radiographic knee OA.
Adjustments will be made for age, gender, body mass index and level of physical activity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants of the BLSA who have had 1 or more DXA scans AND who were either classified as having radiographic knee OA (Kellgren & Lawrence 2 or higher) or as having no radiographic knee OA on two or more xrays (KL 0-1)
排除标准
- •Diagnosis of rheumatoid arthritis
- •Diagnosis of malignancy
- •Reported use of prednisone and other immunosuppressive medications or insulin
结局指标
主要结局
Changes in inflammatory marker c-reactive protein
时间窗: 3 to 5 years
次要结局
- Changes in other biomarkers: inflammatory, metabolic, bone, and joint(3 to 5 years)
研究者
研究点 (1)
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