Effect of Deep Brain Stimulation on Gastrointestinal (GI) Motility
Not Applicable
Completed
- Conditions
- Parkinson's Disease
- Interventions
- Device: Deep brain stimulation
- Registration Number
- NCT01081457
- Lead Sponsor
- University Hospital, Rouen
- Brief Summary
Parkinson's disease is characterized by extra-pyramidal symptoms as well as digestive involvement with gastrointestinal motility (GI) impairment. Deep brain stimulation has been recently developed as a successful treatment for extrapyramidal symptoms. In addition, preliminary reports suggest that this therapy might be successful to relieve GI symptoms as well. The aim of this study is therefore to assess the effect of deep brain stimulation on GI voluntary as well as involuntary motility.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- patient over 18 yo
- patient with Parkinson's disease implanted for deep brain stimulation
- patient responders to deep brain stimulation (UPDRS improved by at least 40%)
- patient covered by the french health care system
- patient not taking anti-parkinsonian medication the day before evaluation
- French speaking
Exclusion Criteria
- patient below 18 yo
- pregnancy
- Severe psychiatric or cognitive disorders
- diabetes mellitus
- morbid obesity
- compulsive eating disorders
- diffuse GI motility impairment (except Parkinson's disease)
- other evolutive neurologic disorders
- previous history of significant GI resection
- inability to swallow or defecate when asked
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description ON Deep brain stimulation Stimulator switched ON OFF Deep brain stimulation Stimulator switched OFF
- Primary Outcome Measures
Name Time Method Anal pressure 2 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Rouen University Hospital
š«š·Rouen, France